Natural Product (NP) Details
| General Information of the NP (ID: NP3788) | |||||
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| Name |
Rosmarinic acid
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| Synonyms |
Rosemary acid; (R)-rosmarinic acid; UNII-MQE6XG29YI; Rosmarinate; MQE6XG29YI; CHEMBL324842; CHEBI:50371; Labiatenic acid; C18H16O8; (R)-O-(3,4-Dihydroxycinnamoyl)-3-(3,4- dihydroxyphenyl)lactic acid; 3,4-Dihydroxycinnamic acid (R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethyl ester; (2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyloxy]propanoic acid; 537-15-5; Rosemaric acid; (2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-propanoic acid
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| Species Origin | Salvia rosmarinus ... | Click to Show/Hide | |||
| Salvia rosmarinus | |||||
| Salvia miltiorrhiza | |||||
| Mentha canadensis | |||||
| Salvia flava | |||||
| Salvia bowleyana | |||||
| Disease | Rheumatoid arthritis [ICD-11: FA20] | Investigative | [1] | ||
| Structure |
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| Formula |
C18H16O8
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| PubChem CID | |||||
| Canonical SMILES |
C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O
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| InChI |
1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1
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| InChIKey |
DOUMFZQKYFQNTF-WUTVXBCWSA-N
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| CAS Number |
CAS 20283-92-5
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| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Drug(s) Whose Resistance can be Reversed by This NP | ||||||
| Cisplatin | Bladder cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Molecule(s)
Regulation |
Down-regulation | Expression | FOXM1 | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-OV-3 | CVCL_0532 | Ovarian serous cystadenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Rosmarinic acid methyl ester regulates ovarian cancer cell migration and reverses cisplatin resistance by inhibiting the expression of forkhead box M1. | |||||
| Target and Pathway | ||||
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| Target(s) | Bcl-2-like protein 3 (MCL1) | Molecule Info | [3] | |
| Tyrosinase (TYR) | Molecule Info | [1] | ||
| BioCyc | (S)-reticuline biosynthesis | Click to Show/Hide | ||
| 2 | Eumelanin biosynthesis | |||
| 3 | L-dopachrome biosynthesis | |||
| KEGG Pathway | PI3K-Akt signaling pathway | Click to Show/Hide | ||
| 2 | MicroRNAs in cancer | |||
| 3 | Tyrosine metabolism | |||
| 4 | Riboflavin metabolism | |||
| 5 | Metabolic pathways | |||
| 6 | Melanogenesis | |||
| NetPath Pathway | TCR Signaling Pathway | Click to Show/Hide | ||
| Panther Pathway | Apoptosis signaling pathway | Click to Show/Hide | ||
| 2 | CCKR signaling map ST | |||
| Pathwhiz Pathway | Riboflavin Metabolism | Click to Show/Hide | ||
| 2 | Tyrosine Metabolism | |||
| Pathway Interaction Database | E2F transcription factor network | Click to Show/Hide | ||
| 2 | Direct p53 effectors | |||
| 3 | IL6-mediated signaling events | |||
| 4 | HIF-1-alpha transcription factor network | |||
| WikiPathways | Apoptosis | Click to Show/Hide | ||
| 2 | miR-targeted genes in muscle cell - TarBase | |||
| 3 | miR-targeted genes in lymphocytes - TarBase | |||
| 4 | miR-targeted genes in leukocytes - TarBase | |||
| 5 | Apoptosis Modulation and Signaling | |||
| 6 | Dopamine metabolism | |||
