Molecule Details

General Information of the Molecule

Name

Creatine kinase M-type (CKM)

Synonyms

Creatine kinase M chain; Creatine phosphokinase M-type; M-CK

Gene Name

CKM

Gene ID

1158

Sequence

MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTG
VDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDD
LDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMT
EKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISM
EKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLA
HLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLM
VEMEKKLEKGQSIDDMIPAQK

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Function

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

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Uniprot ID

KCRM_HUMAN

EC Number

EC: 2.7.3.2

Pfam

PF00217 ; PF02807

KEGG ID

hsa1158

A List of Drug Combination(s) Able to Regulate This Molecule

Expression Regulation

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Down-regulation

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Drug Combination 1 Down-regulating the Expression of This Molecule

[1]

Detail(s)

Combination Info

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Name

Acovenoside A NP Info

Doxorubicin Drug Info

Structure

References

Reference 1

The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice. J Pharmacol Exp Ther. 2016 Aug;358(2):262-70.

Molecule Details

Cite NPCDR

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)