Drug Combination Details
| General Information of the Combination (ID: C78446) | |||||
|---|---|---|---|---|---|
| Name | Acovenoside A NP Info | + | Doxorubicin Drug Info | ||
| Structure |
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+ |
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| Disease |
Healthy individual
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CKM | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CRP | Molecule Info | |||
| Down-regulation | Expression | GPT | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL19 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Down-regulation | Activity | IRF3 | Molecule Info |
Pathway MAP
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| Down-regulation | Activity | IRF7 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | LDHA | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | p105 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | RELA | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNNT2 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Up-regulation | GSH level | ||||
| Down-regulation | Nitric oxide level | |||||
| Up-regulation | Total antioxidant capacity | |||||
| In-vivo Model | Male Swiss albino mice weighing 25 +/- 5 g were used in this study. | |||||
| Experimental
Result(s) |
Adjuvant administration of AcoA with doxorubicin could provide a new treatment strategy for the rescue of jeopardized myocardium from doxorubicin-induced cardiomyopathy. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | The Cardenolide Glycoside Acovenoside A Affords Protective Activity in Doxorubicin-Induced Cardiotoxicity in Mice. J Pharmacol Exp Ther. 2016 Aug;358(2):262-70. | |||
