Molecule Details

General Information of the Molecule

Name

Ceramide synthase 4 (CERS4)

Synonyms

CerS4; LAG1 longevity assurance homolog 4; Sphingosine N-acyltransferase CERS4

Gene Name

CERS4

Gene ID

79603

Sequence

MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFI
GLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRR
RRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLY
WWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHD
SSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFF
GYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPL
QLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT

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Function

Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor.

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Uniprot ID

CERS4_HUMAN

EC Number

EC: 2.3.1.24 ; EC: 2.3.1.291 ; EC: 2.3.1.297

Pfam

PF00046 ; PF03798

KEGG ID

hsa79603

A List of Drug Combination(s) Able to Regulate This Molecule

Expression Regulation

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Up-regulation

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Drug Combination 1 Up-regulating the Expression of This Molecule

[1]

Detail(s)

Combination Info

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Name

Celastrol NP Info

Doxorubicin Drug Info

Structure

References

Reference 1

Hydrogel-mediated delivery of celastrol and doxorubicin induces a synergistic effect on tumor regression via upregulation of ceramides. Nanoscale. 2020 Sep 21;12(35):18463-18475.

Molecule Details

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Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (suilab@hznu.edu.cn)