Molecule Details
| General Information of the Molecule | ||||
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| Name |
Neuronal acetylcholine receptor alpha-2 (CHRNA2)
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| Synonyms |
CHRNA2
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| Gene Name |
CHRNA2
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| Gene ID | ||||
| Sequence |
MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED
RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI Click to Show/Hide
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| Function |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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| Uniprot ID | ||||
| Pfam | ||||
| TTD ID | ||||
| Natural Product(s) of This Target | ||||
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| 1 | Choline | NP Info | Phase 3 | Saccharomyces cerevisiae |
| 2 | d-tubocurarine | NP Info | Approved | Chondrodendron tomentosum |
| Drug(s) of This Target | ||||
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| 1 | Vecuronium | Drug Info | Approved | Tonus and reflex abnormality |