Drug Combination Details
| General Information of the Combination (ID: C01696) | |||||
|---|---|---|---|---|---|
| Name | Polydatin NP Info | + | N-palmitoylethanolamine Drug Info | ||
| Structure |
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+ |
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| Disease |
Discovery agent
[ICD-11: N.A.]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ICAM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL1B | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | NOS2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VCAM1 | Molecule Info |
Pathway MAP
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| In-vivo Model | The mice were anesthetized by sevoflurane inhalation, the left common carotid artery was exposed through a small midline incision in the neck and completely ligated near the carotid bifurcation. | |||||
| Experimental
Result(s) |
Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Palmitoylethanolamide and Polydatin combination reduces inflammation and oxidative stress in vascular injury. Pharmacol Res. 2017 Sep;123:83-92. | |||
