Drug Combination Details
| General Information of the Combination (ID: C02032) | |||||
|---|---|---|---|---|---|
| Name | Sulforaphane NP Info | + | Acetazolamide Drug Info | ||
| Structure |
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+ |
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| Disease |
Bladder cancer
[ICD-11: 2C94]
|
Investigative | [1] | ||
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Lung cancer
[ICD-11: 2C25]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | mTOR | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PIK3CB | Molecule Info |
Pathway MAP
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| In-vitro Model | RT112(H) | CVCL_1670 | Bladder carcinoma | Homo sapiens | ||
| HTB-9 | Bladder carcinoma | Homo sapiens | ||||
| Experimental
Result(s) |
Combination AZ + SFN treatment induced dose-dependent suppression of growth, produced a potent anti-proliferative and anti-clonogenic effect, and induced apoptosis through caspase-3 and PARP activation. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | NANOGNB | Molecule Info | ||
| Down-regulation | Expression | POU5F1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SOX2 | Molecule Info |
Pathway MAP
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| In-vitro Model | NCI-H727 | CVCL_1584 | Lung carcinoid tumor | Homo sapiens | ||
| NCI-H720 | CVCL_1583 | Lung carcinoid tumor | Homo sapiens | |||
| In-vivo Model | H727 and H720 parental and 3rd generation spheroid cells (3 * 104) were injected into the subcutaneous inguinal fat pad of NOD/SCID mice. | |||||
| Experimental
Result(s) |
AZ + SFN combination were effective in inhibiting tumor cell growth, spheroid formation and in reducing tumor formation in immunocompromised mice. | |||||
| Experiment 3 Reporting the Effect of This Combination | [3] | |||||
| In-vitro Model | NCI-H727 | CVCL_1584 | Lung carcinoid tumor | Homo sapiens | ||
| NCI-H720 | CVCL_1583 | Lung carcinoid tumor | Homo sapiens | |||
| In-vivo Model | H-727 and H-720 cells (2 * 106) were injected into the subcutaneous inguinal fat pad of NOD/SCID mice. | |||||
| Experimental
Result(s) |
Treatment of H-727 and H-720 subcutaneous xenografts in NOD/SCID mice with the combination of AZ + SFN for two weeks demonstrated highly significant growth inhibition and reduction of 5-HT content and reduced the invasive capacity of H-727 tumor cells. | |||||
