Drug Combination Details
| General Information of the Combination (ID: C03836) | |||||
|---|---|---|---|---|---|
| Name | Quercetin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [1] | ||
|
Esophageal cancer
[ICD-11: 2B70]
|
Investigative | [2] | |||
|
Hepatocellular carcinoma
[ICD-11: 2C12]
|
Investigative | [3] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAD | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
|
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| In-vitro Model | Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | ||
| SMMC-7721 | CVCL_0534 | Hepatocellular carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Quercetin induces apoptosis and enhances 5-FU therapeutic efficacy in hepatocellular carcinoma. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | EC9706 | CVCL_E307 | Esophageal squamous cell carcinoma | Homo sapiens | ||
| Eca-109 | CVCL_6898 | Esophageal squamous cell carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Quercetin enhances the effects of 5-fluorouracil-mediated growth inhibition and apoptosis of esophageal cancer cells by inhibiting NF-KappaB. | |||||
| Experiment 3 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | Co-115 | CVCL_D102 | Colon adenocarcinoma | Homo sapiens | ||
| HCT 15 | CVCL_0292 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation. | |||||
