Drug Combination Details
| General Information of the Combination (ID: C04593) | |||||
|---|---|---|---|---|---|
| Name | Carnosic acid NP Info | + | Tamoxifen Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAD | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BAK | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP8 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TNFRSF10C | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TNFRSF10D | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TNFSF10 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP73 | Molecule Info |
Pathway MAP
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| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| T-47D | CVCL_0553 | Invasive breast carcinoma | Homo sapiens | |||
| In-vivo Model | 5*105 MCF-7 cells were subcutaneously injected into the dorsal flanks of athymic nude mice. | |||||
| Experimental
Result(s) |
Carnosic acid cooperates with tamoxifen to induce apoptosis associated with Caspase-3 activation in breast cancer cells in vitro and in vivo. | |||||
