Drug Combination Details
| General Information of the Combination (ID: C05119) | |||||
|---|---|---|---|---|---|
| Name | Triptolide NP Info | + | Gemcitabine Drug Info | ||
| Structure |
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+ |
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| Disease |
Pancreatic cancer
[ICD-11: 2C10]
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Investigative | [1] | ||
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Bladder cancer
[ICD-11: 2C94]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CHK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | H2AFX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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| In-vitro Model | BxPC-3 | CVCL_0186 | Pancreatic ductal adenocarcinoma | Homo sapiens | ||
| PANC-1 | CVCL_0480 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Triptolide synergistically increased gemcitabine-induced cell growth inhibition and apoptosis, in addition to the cooperative regulation of B-cell lymphoma 2 family proteins and loss of mitochondrial membrane potential. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CAT | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNA1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNA2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK4 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDK6 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | SOD Mn | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Up-regulation | ROS generation | ||||
| In-vitro Model | EJ | CVCL_ZC18 | B-cell lymphoma | Homo sapiens | ||
| UM-UC-3 | CVCL_1783 | Bladder carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
The combination of GEM plus TPL showed significantly enhanced anticancer effects compared to those of GEM or TPL alone. | |||||
