Drug Combination Details
| General Information of the Combination (ID: C08577) | |||||
|---|---|---|---|---|---|
| Name | Epigallocatechin gallate NP Info | + | Enoxacin Drug Info | ||
| Structure |
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+ |
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| Disease |
Cervical cancer
[ICD-11: 2C77]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP7 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HeLa | CVCL_0030 | Endocervical adenocarcinoma | Homo sapiens | ||
| C-33 A | CVCL_1094 | Cervical squamous cell carcinoma | Homo sapiens | |||
| WI-38 | CVCL_0579 | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
EGCG functions synergistically against cancer cell proliferation in combined treatment with enoxacin. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Enoxacin and Epigallocatechin Gallate (EGCG) Act Synergistically to Inhibit the Growth of Cervical Cancer Cells in Culture. Molecules. 2019 Apr 22;24(8):1580. | |||
