Drug Combination Details
| General Information of the Combination (ID: C15951) | |||||
|---|---|---|---|---|---|
| Name | Chlorogenic acid NP Info | + | Methotrexate Drug Info | ||
| Structure |
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+ |
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| Disease |
Healthy individual
[ICD-11: N.A.]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | GPT | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | GPT | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | LDHA | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | NOS2 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Attennuation | Pro-inflammatory and apoptotic mediators | ||||
| Improvement | Antioxidant competence | |||||
| In-vivo Model | 6-8 weeks old Male Wistar rats (150-200 g) were use in this study. | |||||
| Experimental
Result(s) |
CGA has perfective effect against MTX-induced liver injury. | |||||
