Drug Combination Details
| General Information of the Combination (ID: C23676) | |||||
|---|---|---|---|---|---|
| Name | Apigenin NP Info | + | ABT-263 Drug Info | ||
| Structure |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
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Investigative | [1] | ||
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Lung cancer
[ICD-11: 2C25]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | FOXO3 | Molecule Info |
Pathway MAP
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| In-vitro Model | NCI-H1975 | CVCL_1511 | Lung adenocarcinoma | Homo sapiens | ||
| HCC827 | CVCL_2063 | Lung adenocarcinoma | Homo sapiens | |||
| NCI-H1650 | CVCL_1483 | Lung adenocarcinoma | Homo sapiens | |||
| NCI-H3255 | CVCL_6831 | Lung adenocarcinoma | Homo sapiens | |||
| SK-MEL-28 | CVCL_0526 | Cutaneous melanoma | Homo sapiens | |||
| Experimental
Result(s) |
Apigenin upregulated the expression of Noxa in EGFRm tumor cells by targeting the AKT-FoxO3a pathway, thereby synergizing with ABT-263 to suppress tumor cell growth and proliferation in vitro and in vivo. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BCL2L11 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | ERK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| DLD-1 | CVCL_0248 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Apigenin sensitizes colon cancer cells to antitumor activity of ABT-263 via inhibition of the Mcl-1, AKT, and ERK prosurvival regulators. | |||||
