Drug Combination Details
| General Information of the Combination (ID: C25294) | |||||
|---|---|---|---|---|---|
| Name | Luteolin NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [1] | ||
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Discovery agent
[ICD-11: N.A.]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | ||||||
| Molecule(s)
Regulation |
. | Expression | GPSM2 | Molecule Info | ||
| In-vitro Model | RKO | CVCL_0504 | Colon carcinoma | Homo sapiens | ||
| SW480 | CVCL_0546 | Colon adenocarcinoma | Homo sapiens | |||
| In-vivo Model | RKO or SW480 cells xenograft model | |||||
| Experimental
Result(s) |
(1) Luteolin inhibits the proliferation and invasion of RKO and SW480 cells, thereby promoting G2/M phase arrest and COAD cell apoptosis. (2) The pharmacological mechanism of luteolin in the treatment of COAD involves targeting GPSM2 and mediating the FOXO signaling pathway. (3) In vivo experiments once again validated our findings in vitro and also demonstrated the synergistic effect of traditional medicine with chemotherapy drugs. | |||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | DRAM1 | Molecule Info | |||
| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vivo Model | Solid tumors were induced by intramuscular inoculation of 0.2 mL of ascetic fluid, containing approximately 2.5*106 Ehrlich asites carcinoma cells, in the right thigh of the hind limb of each mouse. | |||||
| Experimental
Result(s) |
Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced Solid Ehrlich Carcinoma. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | Hep-G2 | CVCL_0027 | Hepatocellular carcinoma | Homo sapiens | ||
| BEL-7402 | CVCL_5492 | Human hepatocellular carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism. | |||||
