Drug Combination Details
| General Information of the Combination (ID: C27661) | |||||
|---|---|---|---|---|---|
| Name | Oxymatrine NP Info | + | Sodium ferulate Drug Info | ||
| Structure |
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+ |
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| Disease |
Substance abuse
[ICD-11: 6C40]
|
Investigative | [1] | ||
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Sepsis
[ICD-11: 1G40-1G41]
|
Investigative | [2] | |||
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Acute lung injury
[ICD-11: NB32]
|
Investigative | [3] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IL19 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vivo Model | Swiss mice (18-20 g) and Sprague-Dawley rats (120-150 g) were used in this study. | |||||
| Experimental
Result(s) |
SF and OMT combination had an obvious protective effect on PQ-induced lung injury. The anti-infammatory and antioxidant effect might be involved in the mechanism. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IL19 | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
|
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| In-vivo Model | Swiss male mice (18-22 g) were used in this study. | |||||
| Experimental
Result(s) |
The combination of SF and OMT induced protective effects against CLP-induced lethal sepsis of mice. The possible mechanism of these effects may be associated with the alleviation of systemic inflammation and diminishment of oxidative injury. | |||||
| Experiment 3 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IL19 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
|
||
| In-vivo Model | The ethanol-induced liver damage mouse model was constructed on Swiss male mice. | |||||
| Experimental
Result(s) |
The combination of SF and OMT had a protective effect on ethanol-induced liver damage in mice and that antioxidation and anti-inflammatory effects mightbe involved in this protective mechanism. | |||||
