Drug Combination Details
| General Information of the Combination (ID: C36243) | |||||
|---|---|---|---|---|---|
| Name | Pinocembrin NP Info | + | Simvastatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Atherosclerosis
[ICD-11: BD40]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vivo Model | ApoE / mice (8 weeks old) were fed a high fat diet (21% fat and 0.15% cholesterol). | |||||
| Experimental
Result(s) |
The combination of simvastatin and pinocembrin synergistically inhibited atherosclerotic lesion development in ApoE-/- mice with hyperlipidemia, which is partially dependent on the protective of vascular endothelium. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in ApoE-deficient mice. Lipids Health Dis. 2012 Dec 5;11:166. | |||
