Drug Combination Details
| General Information of the Combination (ID: C36772) | |||||
|---|---|---|---|---|---|
| Name | Hesperetin NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Stomach cancer
[ICD-11: 2B72]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | AIFM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCND1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PTEN | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PTEN | Molecule Info |
Pathway MAP
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| In-vitro Model | GES-1 | CVCL_EQ22 | Healthy | Homo sapiens | ||
| HGC-27 | CVCL_1279 | Gastric carcinoma | Homo sapiens | |||
| SGC-7901 | CVCL_0520 | Human gastric cancer | Homo sapiens | |||
| MGC-803 | CVCL_5334 | Gastric mucinous adenocarcinoma | Homo sapiens | |||
| HGC-27/DDP | Gastric carcinoma | Homo sapiens | ||||
| In-vivo Model | HGC-27 cells were suspended in 100 ul of PBS, and then implanted into the dorsal area, subcutaneously, of male BALB/c nude mice. | |||||
| Experimental
Result(s) |
Hesperetin could inhibit the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT signaling pathway and induce the mitochondrial pathway via upregulating PTEN expression, thereby significantly enhancing DDP's anti-tumor effect on GC. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Hesperetin Promotes Cisplatin-Induced Apoptosis of Gastric Cancer In Vitro and In Vivo by Upregulating PTEN Expression. Front Pharmacol. 2020 Aug 27;11:1326. | |||
