Drug Combination Details
| General Information of the Combination (ID: C38237) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | Busulfan Drug Info | ||
| Structure |
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+ |
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| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | KG-1a | CVCL_1824 | Adult acute myeloid leukemia | Homo sapiens | ||
| HL-60 | CVCL_0002 | Adult acute myeloid leukemia | Homo sapiens | |||
| Experimental
Result(s) |
Curcumin could increase the sensitivity of leukemia stem-like KG1a cells to busulfan by downregulating the expression of survivin. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Curcumin Enhanced Busulfan-Induced Apoptosis through Downregulating the Expression of Survivin in Leukemia Stem-Like KG1a Cells. Biomed Res Int. 2015;2015:630397. | |||
