Drug Combination Details
| General Information of the Combination (ID: C43718) | |||||
|---|---|---|---|---|---|
| Name | Gossypol NP Info | + | Imatinib Drug Info | ||
| Structure |
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| Disease |
Acute lymphoblastic leukemia
[ICD-11: 2B33]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Up-regulation | Cytochrome c release | ||||
| In-vitro Model | K-562 | CVCL_0004 | Chronic myelogenous leukemia | Homo sapiens | ||
| Experimental
Result(s) |
Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | (-)Gossypol and its combination with imatinib induce apoptosis in human chronic myeloid leukemic cells. Leuk Lymphoma. 2007 Nov;48(11):2204-12. | |||
