Drug Combination Details
| General Information of the Combination (ID: C48730) | |||||
|---|---|---|---|---|---|
| Name | Ursolic acid NP Info | + | Doxorubicin Drug Info | ||
| Structure |
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+ |
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| Disease |
Kaposi sarcoma
[ICD-11: 2B57]
|
Investigative | [1] | ||
|
Breast cancer
[ICD-11: 2C60]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | ||||||
| Molecule(s)
Regulation |
. | Expression | PARP | Molecule Info |
Pathway MAP
|
|
| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
significantly decreased PARP, and significantly increased cleaved caspase-9/caspase-9 and cleaved-PARP/PARP protein expression levels following treatment with the combination of 15 uM UA + 1.5 uM DOX compared with the single treatments in HCT116 and HT-29 cells | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Activity | AKT1 | Molecule Info |
Pathway MAP
|
|
| Down-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| In-vitro Model | SW982 | CVCL_1734 | Biphasic synovial sarcoma | Homo sapiens | ||
| SK-UT-1 | CVCL_0533 | Uterine corpus leiomyosarcoma | Homo sapiens | |||
| HT-1080 | CVCL_0317 | Fibrosarcoma | Homo sapiens | |||
| Experimental
Result(s) |
Down-regulation of AKT signalling by ursolic acid induces intrinsic apoptosis and sensitization to doxorubicin in soft tissue sarcoma. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Biological
Regulation |
Disruption | Glutamine metabolism | ||||
| Disruption | Synthesis of amino acids | |||||
| Down-regulation | P-gp efflux | |||||
| Disruption | Glycolysis | |||||
| Disruption | TCA cycle | |||||
| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Combination of UA and Dox could reverse the MDR in breast cancer cells by inhibition of P-gp function and disruption of the metabolism of energy and related amino acids. | |||||
