Drug Combination Details
| General Information of the Combination (ID: C52710) | |||||
|---|---|---|---|---|---|
| Name | Sesquiterpene lactone NP Info | + | Benznidazole Drug Info | ||
| Structure |
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+ |
|
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| Disease |
Chagas disease
[ICD-11: 1F53]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | IFNG | Molecule Info |
Pathway MAP
|
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| Down-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| In-vivo Model | Five groups of 10 female Swiss mice weighing approximately 37 g were used in this study. | |||||
| Experimental
Result(s) |
The combination of tagitinin C and Bz exerts potent antiparasitic, immunomodulatory and cardioprotective effects. | |||||
