Drug Details

General Information of the Drug (ID: DR0374)
Name
Benznidazole
Synonyms
BENZNIDAZOLE; 22994-85-0; Radanil; Benznidazol; Benzonidazole; Benznidazolum; Ro 07-1051; 1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)-; N-Benzyl-2-nitroimidazole-1-acetamide; N-Benzyl-2-nitroimidazol-1-yl-acetamide; N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide; 2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide; UNII-YC42NRJ1ZD; N-Benzyl-2-nitro-1H-imidazole-1-acetamide; N-benzyl-2-(2-nitroimidazol-1-yl)acetamide; Imidazole-1-acetamide, N-benzyl-2-nitro-; YC42NRJ1ZD; CHEMBL110; MMV688773; NSC299972; NSC-299972; Ro-7-1051; NCGC00166238-01; Ro 07-1051;Ro 71051; DSSTox_CID_26570; DSSTox_RID_81729; DSSTox_GSID_46570; Rochagan; Benznidazol [INN-Spanish]; Benznidazolum [INN-Latin]; Ro 71051; SMR000857153; NSC 299972; CAS-22994-85-0; CCRIS 2200; N-benzyl-2-nitro-1-imidazoleacetamide; BRN 0551486; Ragonil; Acetamide, N-benzyl-2-(nitroimidazol-1-yl)-; benznidazole (TN); Rochagan (TN); Radanil (TN); Benznidazole (USAN/INN); Benznidazole [USAN:INN]; SCHEMBL45081; MLS001332409; MLS001332410; MLS001360496; DTXSID9046570; SCHEMBL22493029; ZINC56949; CHEBI:133833; HMS2233G13; HMS3369C11; HY-B1548; Tox21_112364; BDBM50089916; MFCD00243089; s3741; AKOS015916722; AKOS024283499; Tox21_112364_1; CCG-267054; DB11989; MCULE-5592629788; 2-(2-nitroimidazolyl)-N-benzylacetamide; NCGC00166238-02; AK323200; AS-68694; QC-10765; ST069365; CS-0013411; FT-0662547; RO-07-1051; Benznidazol (Ro 07-1051; Ro 71051); D02489; N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide; N-benzyl-2-(2-nitro-1Himidazol-1-yl)acetamide; N-benzyl-2-(2-nitro-1H-imidazol-5-yl)acetamide; N-Benzyl-2-nitro-1H-imidazole-1-acetamide, 97%; Q425300; SR-01000841264; 2-(2-nitroimidazol-1-yl)-N-(phenylmethyl)acetamide; J-014932; SR-01000841264-3; BRD-K56156805-001-05-4; 1H-Imidazole-1-acetamide, 2-nitro-N-(phenylmethyl)- (9CI); N-Benzyl-2-(2-nitro-imidazol-1-yl)-acetamide (Benznidazole); Pyridinium,1-dodecyl-2-[(hydroxyimino)methyl]-,iodide(1:1)
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Molecular Type
Small molecule
Disease Chagas disease [ICD-11: 1F53] Approved [1]
Structure
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2D MOL

3D MOL

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Formula
C12H12N4O3
PubChem CID
31593
Canonical SMILES
C1=CC=C(C=C1)CNC(=O)CN2C=CN=C2[N+](=O)[O-]
InChI
1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17)
InChIKey
CULUWZNBISUWAS-UHFFFAOYSA-N
CAS Number
CAS 22994-85-0
ChEBI ID
CHEBI:133833
TTD Drug ID
D04XGT
DrugBank ID
DB11989
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Sesquiterpene lactone      Apis mellifera     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression IFNG  Molecule Info 
Pathway MAP
Down-regulation Expression TNF  Molecule Info 
Pathway MAP
                    In-vivo Model Five groups of 10 female Swiss mice weighing approximately 37 g were used in this study.
                    Experimental
                    Result(s)		 The combination of tagitinin C and Bz exerts potent antiparasitic, immunomodulatory and cardioprotective effects.
References
Reference 1 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
Reference 2 Sesquiterpene lactone potentiates the immunomodulatory, antiparasitic and cardioprotective effects on anti-Trypanosoma cruzi specific chemotherapy. Int Immunopharmacol. 2019 Dec;77:105961.
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