Drug Combination Details
| General Information of the Combination (ID: C57091) | |||||
|---|---|---|---|---|---|
| Name | Honokiol NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Lip/oral cavity/pharynx neoplasm
[ICD-11: 2B6E]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | EGFR | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Up-regulation | Cytochrome c release | ||||
| In-vitro Model | HSC-3 | CVCL_1288 | Tongue squamous cell carcinoma | Homo sapiens | ||
| HSC-4 | CVCL_1289 | Tongue squamous cell carcinoma | Homo sapiens | |||
| In-vivo Model | A total of 2*106 HSC-3 cells were suspended in 100 uL serum-free DMEM and injected subcutaneously into the right flank of BALB/c nude mice to establish OSCC xenograft models. | |||||
| Experimental
Result(s) |
HNK and 5-FU exert a synergistic therapeutic effect on OSCC by inducing apoptosis. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Synergistic effect of honokiol and 5-fluorouracil on apoptosis of oral squamous cell carcinoma cells. J Oral Pathol Med. 2017 Mar;46(3):201-207. | |||
