Drug Combination Details
| General Information of the Combination (ID: C58722) | |||||
|---|---|---|---|---|---|
| Name | Celastrol NP Info | + | TNF-related apoptosis inducing ligand Drug Info | ||
| Structure |
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+ |
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| Disease |
Lung cancer
[ICD-11: 2C25]
|
Investigative | [1] | ||
|
Brain cancer
[ICD-11: 2A00]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Cleavage | CASP8 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | SQSTM1 | Molecule Info |
Pathway MAP
|
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| HCC15 | CVCL_2057 | Lung squamous cell carcinoma | Homo sapiens | |||
| Calu-3 | CVCL_0609 | Lung adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Cleavage | CASP8 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | U-87MG ATCC | CVCL_0022 | Glioblastoma | Homo sapiens | ||
| U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | |||
| LN-229 | CVCL_0393 | Glioblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Activity | CASP3 | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Activity | CASP8 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | SQSTM1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| HCC15 | CVCL_2057 | Lung squamous cell carcinoma | Homo sapiens | |||
| Calu-3 | CVCL_0609 | Lung adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL-induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Cleavage | CASP8 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | U-87MG ATCC | CVCL_0022 | Glioblastoma | Homo sapiens | ||
| U-251MG | CVCL_0021 | Astrocytoma | Homo sapiens | |||
| LN-229 | CVCL_0393 | Glioblastoma | Homo sapiens | |||
| Experimental
Result(s) |
Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway. | |||||
