Drug Combination Details
| General Information of the Combination (ID: C59500) | |||||
|---|---|---|---|---|---|
| Name | Flavopiridol NP Info | + | Bortezomib Drug Info | ||
| Structure |
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+ |
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| Disease |
B-cell lymphoma
[ICD-11: 2A86]
|
Phase 1 | [1] | ||
|
Chronic myelogenous leukaemia
[ICD-11: 2A20]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | CRKL | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | DIABLO | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | ERK2 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | HCK | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | JNK1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | JTK8 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | NFKBIA | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | STAT3 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | STAT5B | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Loss of mitochondrial membrane potential | ||||
| Up-regulation | Cytochrome c release | |||||
| In-vitro Model | K-562 | CVCL_0004 | Chronic myelogenous leukemia | Homo sapiens | ||
| LAMA-84 | CVCL_0388 | Chronic myelogenous leukemia | Homo sapiens | |||
| U-937 | CVCL_0007 | Adult acute monocytic leukemia | Homo sapiens | |||
| HL-60 | CVCL_0002 | Adult acute myeloid leukemia | Homo sapiens | |||
| Raji | CVCL_0511 | EBV-related Burkitt lymphoma | Homo sapiens | |||
| Jurkat | CVCL_0065 | T acute lymphoblastic leukemia | Homo sapiens | |||
| CCRF-CEM | CVCL_0207 | T acute lymphoblastic leukemia | Homo sapiens | |||
| Experimental
Result(s) |
Bortezomib interacts synergistically with flavopiridol to induce mitochondrial dysfunction and apoptosis, blockade of the IkappaB/NF-kappaB pathway and activation of the SAPK/JNK cascade. | |||||
