Molecule Details

General Information of the Molecule

Name

Direct IAP-binding protein (DIABLO)

Synonyms

Smac protein; Smac; Second mitochondria-derived activator of caspase; Direct IAP binding protein with low pI; Diablo homolog, mitochondrial; Direct IAP-binding protein with low pI

Gene Name

DIABLO

Gene ID

56616

Sequence

MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTIGFGVTLCAVPIA
QKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSL
LGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQAS
ITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRED

Click to Show/Hide

Function

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Click to Show/Hide

Uniprot ID

DBLOH_HUMAN

Pfam

PF09057

KEGG ID

hsa56616

TTD ID

T78150

A List of Drug Combination(s) Able to Regulate This Molecule

Expression Regulation

Click to Show/Hide the Drug Combination Regulating This Molecule

Up-regulation

Click to Show/Hide

Drug Combination 1 Up-regulating the Expression of This Molecule

[1]

Detail(s)

Combination Info

click to show the detail info of this combination

Name

Genistein NP Info

HA14-1 Drug Info

Structure

Drug Combination 2 Up-regulating the Expression of This Molecule

[2]

Detail(s)

Combination Info

click to show the detail info of this combination

Name

Gallic acid NP Info

Cisplatin Drug Info

Structure

Drug Combination 3 Up-regulating the Expression of This Molecule

[3]

Detail(s)

Combination Info

click to show the detail info of this combination

Name

Flavopiridol NP Info

Bortezomib Drug Info

Structure

Drug Combination 4 Up-regulating the Expression of This Molecule

[4]

Detail(s)

Combination Info

click to show the detail info of this combination

Name

Flavopiridol NP Info

Imatinib Drug Info

Structure

References

Reference 1

Bcl-2 inhibitor HA14-1 and genistein together adeptly down regulated survival factors and activated cysteine proteases for apoptosis in human malignant neuroblastoma SK-N-BE2 and SH-SY5Y cells. Brain Res. 2009 Aug 4;1283:155-66.

Reference 2

Gallic acid has anticancer activity and enhances the anticancer effects of cisplatin in non?small cell lung cancer A549 cells via the JAK/STAT3 signaling pathway. Oncol Rep. 2019 Mar;41(3):1779-1788.

Reference 3

Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood. 2004 Jul 15;104(2):509-18.

Reference 4

Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells. Clin Cancer Res. 2002 Sep;8(9):2976-84.

Molecule Details

Cite NPCDR

Visitor Map

Correspondence

Prof. Feng ZHU (zhufeng@zju.edu.cn)

Prof. Xinbing SUI (hzzju@hznu.edu.cn)