Drug Combination Details
| General Information of the Combination (ID: C75746) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | Oxaliplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Colorectal cancer
[ICD-11: 2B91]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Cell cycle arrest in S and G2/M phase | ||||
| Up-regulation | Ratio of Bax to Bcl-2 | |||||
| In-vitro Model | LoVo | CVCL_0399 | Colon adenocarcinoma | Homo sapiens | ||
| In-vivo Model | LoVo cells were suspended in serum-free medium and injected subcutaneously into the right flank of the nude mice at 1*106/0.1mL/mouse. | |||||
| Experimental
Result(s) |
Curcumin combined with oxaliplatin effectively suppress colorectal carcinoma in vivo through inducing apoptosis. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | NOTCH1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| In-vivo Model | Female nude mice (6-8 weeks old) were exposed to light halothane anesthesia and were inoculated with 1*106 HCT116 human colorectal cancer cells suspended in matrigel. | |||||
| Experimental
Result(s) |
Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. | |||||
| β. Reversing Drug Resistance by This Combination | ||||||
| Reversing Drug Resistance | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CDH2 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | RELA | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | SMAD2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TGFB1 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| SW480 | CVCL_0546 | Colon adenocarcinoma | Homo sapiens | |||
| In-vivo Model | HCT116/OXA cells were transplanted subcutaneously into the right flank in each BALB/c nude mice (6-8 weeks old, 20+/-2 g weight). | |||||
| Experimental
Result(s) |
Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-beta/Smad2/3 signaling pathway. | |||||
