Drug Combination Details
| General Information of the Combination (ID: C76152) | |||||
|---|---|---|---|---|---|
| Name | Paclitaxel NP Info | + | Alpelisib Drug Info | ||
| Structure |
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| Disease |
Stomach cancer
[ICD-11: 2B72]
|
Phase 2 | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP7 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | H2AFX | Molecule Info |
Pathway MAP
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| In-vitro Model | SNU-1 | CVCL_0099 | Gastric adenocarcinoma | Homo sapiens | ||
| SNU-16 | CVCL_0076 | Gastric adenocarcinoma | Homo sapiens | |||
| SNU-484 | CVCL_0100 | Gastric adenocarcinoma | Homo sapiens | |||
| SNU-638 | CVCL_0102 | Gastric adenocarcinoma | Homo sapiens | |||
| MKN1 | CVCL_1415 | Gastric adenosquamous carcinoma | Homo sapiens | |||
| SNU-601 | CVCL_0101 | Gastric adenocarcinoma | Homo sapiens | |||
| SNU-668 | CVCL_5081 | Gastric adenocarcinoma | Homo sapiens | |||
| AGS | CVCL_0139 | Gastric adenocarcinoma | Homo sapiens | |||
| In-vivo Model | For a xenograft model, 1 * 107 MKN1 cells were implanted subcutaneously into both flanks of each Balb/c mouse. | |||||
| Experimental
Result(s) |
Alpelisib alone or in combination with paclitaxel demonstrated promising anti-tumor activity in in vitro and in vivo models of PIK3CA-mutant GC via inactivating PI3K down-stream molecules, increasing DNA damage response, and apoptosis. | |||||
