Drug Combination Details
| General Information of the Combination (ID: C76406) | |||||
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| Name | Acteoside + Paeoniflorin | + | X-ray irradiation | ||
| Click to Show/Hide the Each NP or Drug Information of This Combination | |||||
| Name | Acteoside NP Info | Drug Info | |||
| Structure |
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| Name | Paeoniflorin NP Info | ||||
| Structure |
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| Disease |
Healthy individual
[ICD-11: N.A.]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. Decreasing Adverse Drug Reaction by This Combination | ||||||
| Decreasing Adverse Drug Reaction | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| In-vitro Model | Human skin fibroblasts | Healthy | Homo sapiens | |||
| Experimental
Result(s) |
Acteoside could protect the cells from X ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl 2 ratio and downregulating the activity of procaspase 3, as well as modulating the mitogen activated protein kinase signaling pathways. | |||||
| References | ||||
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| Reference 1 | Protective effects of acteoside against X?ray?induced damage in human skin fibroblasts. Mol Med Rep. 2015 Aug;12(2):2301-6. | |||
