Drug Combination Details
| General Information of the Combination (ID: C76914) | |||||
|---|---|---|---|---|---|
| Name | Galangin NP Info | + | Cisplatin Drug Info | ||
| Structure |
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| Disease |
Acute myeloid leukemia
[ICD-11: 2A60]
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Investigative | [1] | ||
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Lung cancer
[ICD-11: 2C25]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BID | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | RELA | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | STAT3 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| In-vivo Model | A549/DDP cells were harvested, 5 * 106 cells were in jected subcutaneously into the right oxter of mice. | |||||
| Experimental
Result(s) |
Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-KappaB and Bcl-2/Bax signaling pathways. | |||||
| Experiment 2 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Up-regulation | Apoptotic DNA fragmentation | ||||
| In-vitro Model | HL-60 | CVCL_0002 | Adult acute myeloid leukemia | Homo sapiens | ||
| L1210 | CVCL_0382 | Mouse leukemia | Mus musculus | |||
| Experimental
Result(s) |
Combined treatment with QU and cis-Pt showed synergistic effect. | |||||
