Drug Combination Details
| General Information of the Combination (ID: C79238) | |||||
|---|---|---|---|---|---|
| Name | Gambogic acid NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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| Disease |
Stomach cancer
[ICD-11: 2B72]
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Investigative | [1] | ||
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Colorectal cancer
[ICD-11: 2B91]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PAEP | Molecule Info | |||
| Down-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | BGC-823 | CVCL_3360 | Gastric cancer | Homo sapiens | ||
| In-vivo Model | Forty mice were inoculated sub cutaneously with injections of 1 * 106 BGC-823 cells/mouse. | |||||
| Experimental
Result(s) |
GA attenuated 5-FU-induced apoptosis by modulating metabolic enzymes of 5-FU and the antigastric cancer effect of two drugs combination was much stronger than that of GA or 5-FU alone. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TYMS | Molecule Info |
Pathway MAP
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| In-vitro Model | SW480 | CVCL_0546 | Colon adenocarcinoma | Homo sapiens | ||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Gambogic acid potentiates the chemosensitivity of colorectal cancer cells to 5-fluorouracil by inhibiting proliferation and inducing apoptosis. | |||||
