Drug Combination Details
| General Information of the Combination (ID: C97895) | |||||
|---|---|---|---|---|---|
| Name | Sulforaphane NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Salivary gland adenoid cystic carcinoma
[ICD-11: 2B6A]
|
Investigative | [1] | ||
|
Breast cancer
[ICD-11: 2C60]
|
Investigative | [2] | |||
|
Colon cancer
[ICD-11: 2B90]
|
Investigative | [3] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PIK3CB | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Cell cycle arrest in G2/M phase | ||||
| In-vitro Model | Caco-2 | CVCL_0025 | Colon adenocarcinoma | Homo sapiens | ||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Sulforaphane showed synergistic interaction with 5-fluorouracil involved an intensification of apoptotic cell death. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
|
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| Up-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
| Experimental
Result(s) |
Sulforaphane and 5-fluorouracil have been shown to interact synergistically in the breast cancerMDA-MB-231 cell line, resulting in a significant reduction of the number of live cells compared to alone treatments. | |||||
| Experiment 3 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | RELA | Molecule Info |
Pathway MAP
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| In-vitro Model | ACC-M | CVCL_6874 | Adenoid cystic carcinoma | Homo sapiens | ||
| ACC-2 | CVCL_6872 | Adenoid cystic carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Treatment ACCs cells with SFN and 5-Fu in combination, led to synergistic inhibition on cell growth and a decreased expression in nuclear NF-KappaB p65 protein. | |||||
