Drug Combination Details
| General Information of the Combination (ID: C97955) | |||||
|---|---|---|---|---|---|
| Name | Arsenic trioxide NP Info | + | Thalidomide Drug Info | ||
| Structure |
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+ |
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| Disease |
Multiple myeloma
[ICD-11: 2A83]
|
Phase 2 | [1] | ||
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Acute myeloid leukemia
[ICD-11: 2A60]
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Investigative | [2] | |||
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Acute lymphoblastic leukemia
[ICD-11: 2B33]
|
Investigative | [3] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BECN1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | IL6 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MAP1LC3A | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | MEK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | mTOR | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PIK3CB | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PTEN | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | SQSTM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | ULK1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | VEGFC | Molecule Info |
Pathway MAP
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| In-vitro Model | KG-1 | CVCL_0374 | Adult acute myeloid leukemia | Homo sapiens | ||
| U-937 | CVCL_0007 | Adult acute monocytic leukemia | Homo sapiens | |||
| Experimental
Result(s) |
Arsenic trioxide and thalidomide combination induces autophagy along with apoptosis in acute myeloid cell lines. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vitro Model | U-937 | CVCL_0007 | Adult acute monocytic leukemia | Homo sapiens | ||
| KG-1 | CVCL_0374 | Adult acute myeloid leukemia | Homo sapiens | |||
| Experimental
Result(s) |
Arsenic trioxide and thalidomide combination showed inhibitory effects of on angiogenesis and vascular endothelial growth factor expression in leukemia cells. | |||||
