Drug Combination Details
| General Information of the Combination (ID: C98672) | |||||
|---|---|---|---|---|---|
| Name | Silibinin NP Info | + | Trichostatin A Drug Info | ||
| Structure |
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| Disease |
Lung cancer
[ICD-11: 2C25]
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Investigative | [1] | ||
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Pancreatic cancer
[ICD-11: 2C10]
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Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | POLD1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | XIAP | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Cell cycle arrest in G2/M phase | ||||
| In-vitro Model | NCI-H1299 | CVCL_0060 | Lung large cell carcinoma | Homo sapiens | ||
| NCI-H358 | CVCL_1559 | Lung adenocarcinoma | Homo sapiens | |||
| NCI-H322 | CVCL_1556 | Lung adenocarcinoma | Homo sapiens | |||
| In-vivo Model | Six week old athymic (nu/nu) male nude mice were subcutaneously injected with about three million exponentially growing H1299 cells mixed with equal volume (1:1) of matrigel on the right flank of each mouse. | |||||
| Experimental
Result(s) |
Combinations of TSA with silibinin synergistically augmented the cytotoxic effects of the single agent, which was associated with a dramatic increase in p21 (Cdkn1a). | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CCNA2 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Arrest | Cell cycle arrest in G2/M phase | ||||
| Down-regulation | Ratio of Cyclin B1 to Cdk1 | |||||
| In-vitro Model | BxPC-3 | CVCL_0186 | Pancreatic ductal adenocarcinoma | Homo sapiens | ||
| PaTu 8988s | CVCL_1846 | Pancreatic adenocarcinoma | Homo sapiens | |||
| PANC-1 | CVCL_0480 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| Capan-2 | CVCL_0026 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells. | |||||
