Drug Details
| General Information of the Drug (ID: DR0951) | ||||
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| Name |
Anti-PD-1 antibody
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| Synonyms |
Anti-programmed cell death-1 (anti-PD-1)
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| Disease | Hepatocellular carcinoma [ICD-11: 2C12] | Approved | [1] | |
| Lung cancer [ICD-11: 2C25] | Approved | [1] | ||
| Melanoma [ICD-11: 2C30] | Approved | [1] | ||
| Stomach cancer [ICD-11: 2B72] | Approved | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Curcumin | Hellenia speciosa | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | F2 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | IFNG | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL10 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | IL4 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MDC | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | TGFB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TNF | Molecule Info |
Pathway MAP
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| In-vitro Model | Hep 3B2.1-7 | CVCL_0326 | Childhood hepatocellular carcinoma | Homo sapiens | ||
| CSQT-2 | CVCL_M183 | Adult hepatocellular carcinoma | Homo sapiens | |||
| In-vivo Model | Hep3B cells was subcutaneously injected into the left axilla of each five-week-old healthy BALB/c female nude mice. | |||||
| Experimental
Result(s) |
Curcumin had a synergistic effect with anti-PD-1 to slow Hep3B cell proliferation, activate lymphocytes, inhibit immune evasion, and down-regulate TGF-beta1 expression. | |||||
| Lycopene | Daucus carota | Click to Show/Hide the Molecular Data of This NP | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | IFNG | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | JAK-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | STAT3 | Molecule Info |
Pathway MAP
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| In-vivo Model | Lewis lung carcinoma (LLC) cells (1*106) were injected in the rear flak of C57BL/6 mice. | |||||
| Experimental
Result(s) |
Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells. | |||||
| Target and Pathway | ||||
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| Target(s) | Caterpiller protein 1.1 (NLRP3) | Molecule Info | ||
| Complement decay-accelerating factor (CD55) | Molecule Info | [4] | ||
| E3 ubiquitin-protein ligase synoviolin | Molecule Info | |||
| Golgi phosphoprotein 3-like | Molecule Info | |||
| Heat shock protein 90 alpha (HSP90A) | Molecule Info | |||
| Programmed cell death 1 ligand 1 (PD-L1) | Molecule Info | |||
| Stimulator of interferon genes protein | Molecule Info | |||
| TNF-related apoptosis-inducing ligand (TRAIL) | Molecule Info | [4] | ||
| KEGG Pathway | Cytokine-cytokine receptor interaction | Click to Show/Hide | ||
| 2 | FoxO signaling pathway | |||
| 3 | Apoptosis | |||
| 4 | Natural killer cell mediated cytotoxicity | |||
| 5 | Measles | |||
| 6 | Influenza A | |||
| 7 | Complement and coagulation cascades | |||
| 8 | Hematopoietic cell lineage | |||
| 9 | Viral myocarditis | |||
| NetPath Pathway | IL2 Signaling Pathway | Click to Show/Hide | ||
| 2 | IL4 Signaling Pathway | |||
| 3 | TGF_beta_Receptor Signaling Pathway | |||
| 4 | TNFalpha Signaling Pathway | |||
| 5 | Leptin Signaling Pathway | |||
| 6 | IL5 Signaling Pathway | |||
| 7 | FSH Signaling Pathway | |||
| Panther Pathway | Apoptosis signaling pathway | Click to Show/Hide | ||
| Pathway Interaction Database | TRAIL signaling pathway | Click to Show/Hide | ||
| 2 | Caspase Cascade in Apoptosis | |||
| Reactome | Ligand-dependent caspase activation | Click to Show/Hide | ||
| 2 | Regulation by c-FLIP | |||
| 3 | RIPK1-mediated regulated necrosis | |||
| 4 | CASP8 activity is inhibited | |||
| 5 | Dimerization of procaspase-8 | |||
| 6 | TRAIL signaling | |||
| 7 | Class B/2 (Secretin family receptors) | |||
| 8 | Regulation of Complement cascade | |||
| WikiPathways | Apoptosis | Click to Show/Hide | ||
| 2 | Extrinsic Pathway for Apoptosis | |||
| 3 | Apoptosis Modulation and Signaling | |||
| 4 | TP53 Network | |||
| 5 | Complement and Coagulation Cascades | |||
| 6 | Complement Activation, Classical Pathway | |||
| 7 | Human Complement System | |||
| 8 | GPCR ligand binding | |||
| 9 | Complement cascade | |||
