Drug Details

General Information of the Drug (ID: DR2770)
Name
Arsenite
Disease Prostate cancer [ICD-11: 2C82] Investigative [1]
TTD Drug ID
D0X8KC
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Delphinidin      Aristotelia chilensis     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression p105  Molecule Info 
Pathway MAP
                    In-vitro Model HL-60 CVCL_0002 Adult acute myeloid leukemia Homo sapiens
                    Experimental
                    Result(s)		 Delphinidin-induced sensitization of HL-60 cells to As(III) may lead to dose reduction of As(III) in clinical application, and ultimately contribute to minimizing its side effects.
          Gamabufotalin      Andrias davidianus     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [3]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Down-regulation Expression BIRC5  Molecule Info 
Pathway MAP
Down-regulation Expression CCNB1  Molecule Info 
Pathway MAP
Up-regulation Expression MAP1LC3A  Molecule Info 
Pathway MAP
Up-regulation Phosphorylation p38 beta  Molecule Info 
Pathway MAP
                    In-vitro Model U-87MG ATCC CVCL_0022 Glioblastoma Homo sapiens
U-251MG CVCL_0021 Astrocytoma Homo sapiens
                    Experimental
                    Result(s)		 G2/M arrest, necrosis and autophagy appeared to cooperatively contribute to the synergistic cytotoxicity of AsIII and gamabufotalin.
Target and Pathway
Target(s) Inhibitor of nuclear factor kappa-B kinase (IKK)  Molecule Info  [4]
Pathwhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Click to Show/Hide
2 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Activation of NF-kappaB in B cells Click to Show/Hide
2 NOD1/2 Signaling Pathway
3 RIP-mediated NFkB activation via ZBP1
4 AKT phosphorylates targets in the cytosol
5 p75NTR recruits signalling complexes
6 NF-kB is activated and signals survival
7 FCERI mediated NF-kB activation
8 Interleukin-1 signaling
9 Regulation of TNFR1 signaling
10 TNFR1-induced NFkappaB signaling pathway
11 IKBKB deficiency causes SCID
12 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
13 IkBA variant leads to EDA-ID
14 Dectin-1 mediated noncanonical NF-kB signaling
15 CLEC7A (Dectin-1) signaling
16 Constitutive Signaling by AKT1 E17K in Cancer
17 NIK-->noncanonical NF-kB signaling
18 MAP3K8 (TPL2)-dependent MAPK1/3 activation
19 TRAF6 mediated IRF7 activation
20 TRAF6 mediated NF-kB activation
21 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
22 Negative regulators of RIG-I/MDA5 signaling
23 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
24 IRAK1 recruits IKK complex
25 IKK complex recruitment mediated by RIP1
26 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
WikiPathways Toll-like receptor signaling pathway Click to Show/Hide
2 Estrogen signaling pathway
3 TCR Signaling Pathway
4 Insulin Signaling
5 IL-4 Signaling Pathway
6 MAPK Signaling Pathway
7 NLR Proteins
8 Hair Follicle Development: Induction (Part 1 of 3)
9 MyD88 cascade initiated on plasma membrane
10 Cardiac Hypertrophic Response
11 Cytosolic sensors of pathogen-associated DNA
12 MyD88 dependent cascade initiated on endosome
13 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
14 MyD88:Mal cascade initiated on plasma membrane
15 Fc epsilon receptor (FCERI) signaling
16 MyD88-independent cascade
17 Signaling by the B Cell Receptor (BCR)
18 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
19 Structural Pathway of Interleukin 1 (IL-1)
20 EBV LMP1 signaling
21 Polycystic Kidney Disease Pathway
22 Apoptosis
23 Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
24 BDNF signaling pathway
25 Interleukin-11 Signaling Pathway
26 AGE/RAGE pathway
27 TNF alpha Signaling Pathway
28 B Cell Receptor Signaling Pathway
29 IL17 signaling pathway
30 TWEAK Signaling Pathway
31 Leptin signaling pathway
32 RANKL/RANK Signaling Pathway
33 Signalling by NGF
34 IL-1 signaling pathway
35 TCR signaling
36 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
37 Interleukin-1 signaling
38 Apoptosis Modulation and Signaling
39 Type II diabetes mellitus
40 MicroRNAs in cardiomyocyte hypertrophy
41 Regulation of toll-like receptor signaling pathway
42 Osteopontin Signaling
43 NOD pathway
References
Reference 1 Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. Mol Cell Biochem. 2004 Jan;255(1-2):33-45.
Reference 2 Enhanced cytotoxic effects of arsenite in combination with anthocyanidin compound, delphinidin, against a human leukemia cell line, HL-60. Chem Biol Interact. 2018 Oct 1;294:9-17.
Reference 3 Cytotoxic Effects of Arsenite in Combination With Gamabufotalin Against Human Glioblastoma Cell Lines. Front Oncol. 2021 Mar 16;11:628914.
Reference 4 Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem. 2000 Nov 17;275(46):36062-6.
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