Drug Details
| General Information of the Drug (ID: DR4889) | ||||
|---|---|---|---|---|
| Name |
Interferon alpha-2b
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| Molecular Type |
Protein
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| Disease | Acute lymphoblastic leukemia [ICD-11: 2B33] | Approved | [1] | |
| DrugBank ID | ||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Epigallocatechin gallate | Hamamelis virginiana | Click to Show/Hide the Molecular Data of This NP | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | FAS | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-375 | CVCL_0132 | Amelanotic melanoma | Homo sapiens | ||
| G-361 | CVCL_1220 | Melanoma | Homo sapiens | |||
| Hs 294T | CVCL_0331 | Melanoma | Homo sapiens | |||
| In-vivo Model | Female nu/nu athymic nude mice (6-weeks old) were subcutaneously implanted with 0.5*106 Hs-294T melanoma cells with equal volume of matrigel (in 100L) on the left flanks. | |||||
| Experimental
Result(s) |
EGCG sensitizes melanoma cells to interferon induced growth inhibition in a mouse model of human melanoma. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Interferon alpha/beta receptor 1 (IFNAR1) | Molecule Info | [3] | |
| Interferon alpha/beta receptor 2 (IFNAR2) | Molecule Info | [3] | ||
| KEGG Pathway | Cytokine-cytokine receptor interaction | Click to Show/Hide | ||
| 2 | PI3K-Akt signaling pathway | |||
| 3 | Osteoclast differentiation | |||
| 4 | Toll-like receptor signaling pathway | |||
| 5 | Jak-STAT signaling pathway | |||
| 6 | Natural killer cell mediated cytotoxicity | |||
| 7 | Hepatitis C | |||
| 8 | Hepatitis B | |||
| 9 | Measles | |||
| 10 | Influenza A | |||
| 11 | Herpes simplex infection | |||
| NetPath Pathway | TCR Signaling Pathway | Click to Show/Hide | ||
| 2 | Leptin Signaling Pathway | |||
| Panther Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | Click to Show/Hide | ||
| Pathway Interaction Database | Downstream signaling in naï | Click to Show/Hide | ||
| 2 | ||||
| Reactome | Interferon alpha/beta signaling | Click to Show/Hide | ||
| 2 | Regulation of IFNA signaling | |||
| WikiPathways | Toll-like receptor signaling pathway | Click to Show/Hide | ||
| 2 | Interferon type I signaling pathways | |||
| 3 | Interferon alpha/beta signaling | |||
| 4 | Regulation of toll-like receptor signaling pathway | |||
| 5 | Osteoclast Signaling | |||
