Drug Combination Details
| General Information of the Combination (ID: C53437) | |||||
|---|---|---|---|---|---|
| Name | Epigallocatechin gallate NP Info | + | Interferon alpha-2b Drug Info | ||
| Structure |
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| Disease |
Melanoma
[ICD-11: 2C30]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | FAS | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | A-375 | CVCL_0132 | Amelanotic melanoma | Homo sapiens | ||
| G-361 | CVCL_1220 | Melanoma | Homo sapiens | |||
| Hs 294T | CVCL_0331 | Melanoma | Homo sapiens | |||
| In-vivo Model | Female nu/nu athymic nude mice (6-weeks old) were subcutaneously implanted with 0.5*106 Hs-294T melanoma cells with equal volume of matrigel (in 100L) on the left flanks. | |||||
| Experimental
Result(s) |
EGCG sensitizes melanoma cells to interferon induced growth inhibition in a mouse model of human melanoma. | |||||
