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Drug Details

General Information of the Drug (ID: DR5752)
Name
Androgen
Synonyms
testosterone propionate; 57-85-2; Agovirin; Androlon; Androteston; Aquaviron; Hormoteston; Enarmon; Bio-testiculina; Androtest P; Androsteston; Sterandryl; Testonique; Andronate; Masenate; Orchiol; Orchistin; Pantestin; Propiokan; Solvotest; Synandrol; Synerone; Telipex; Testaform; Testodet; Testodrin; Testogen; Testolets; Testormol; Testosid; Testoxyl; Testrex; Tostrin; Uniteston; Nasdol; Vulvan; Enarmon-oil; Neo-Hombreol; Okasa-Mascul; Andrusol-P; Oreton propionate; Recthormone testosterone; NSC 9166; Testosteron propionate; 17beta-(Propionyloxy)androst-4-en-3-one; Testosterone-17-propionate; Homandren (amps); Androgen; UNII-WI93Z9138A; CHEMBL1170; CHEBI:9466; (17beta)-3-oxoandrost-4-en-17-yl propanoate; (17beta)-3-oxoandrost-4-en-17-yl propionate; Testosterone-17.beta.-propionate; WI93Z9138A; NSC-9166; Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17b)-; [(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] propanoate; NCGC00016254-01; 17-propionyl-17beta-hydroxyandrost-4-en-3-one; DSSTox_CID_16515; DSSTox_RID_79286; DSSTox_GSID_36515; Orchisterone; Testosteroni propionas; CAS-57-85-2; CCRIS 575; Testoviron (ampule); testosteron-17-propionat; Testosterone-17beta propionate; Testosterone-17beta-propionate; Testosterone-17-beta-propionate; EINECS 200-351-1; Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17.beta.)-; AI3-26378; 17beta-Hydroxyandrost-4-en-3-one propionate; 17beta-Hydroxy-4-androsten-3-one 17-propionate; Testosterone propionate [USP:JAN]; Androst-4-en-3-one, 17beta-hydroxy-, propionate; delta(sup 4)-Androstene-17-beta-propionate-3-one; Prestwick_432; 17beta-Hydroxyandrost-4-en-3-one-17beta-propionate; Testex (TN); 17.beta.-(Propionyloxy)androst-4-en-3-one; Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)-; .DELTA.4-androstene-17.beta.-propionate-3-one; 17.beta.-hydroxyandrost-4-en-3-one, propionate; 3-Oxoandrost-4-en-17-yl propionate, (17.beta.)-; Prestwick0_000401; Prestwick1_000401; Prestwick2_000401; Prestwick3_000401; Androst-4-en-3-one, 17.beta.-hydroxy-, propionate; 17-(1-Oxopropoxy)androst-4-en-3-one, (17.beta.)-; Testosterone propionate ciii; SCHEMBL4044; BSPBio_000322; MLS002153796; Testosterone propionate, solid; SPBio_002261; BPBio1_000356; GTPL7100; Testosterone-17.beta.propionate; DTXSID9036515; Testosterone propionate [Androgenic (anabolic) steroids]; NSC9166; HMS1569A04; HMS2096A04; HMS2272K06; HMS3713A04; Testosterone propionate (Agovirin); ZINC490791; HY-B1269; Tox21_110330; Tox21_302270; BBL029912; BDBM50215709; LMST02020076; MFCD00003653; NRB-03689; STK801834; Testosterone propionate (JP17/USP); AKOS005622513; AKOS015842719; Tox21_110330_1; CCG-220401; CS-4905; DB01420; MCULE-8627319345; NCGC00179602-01; NCGC00179602-03; NCGC00179602-06; NCGC00255481-01; AC-12172; AC-33160; SMR000058348; VS-09499; BCP0726000215; C08158; D00959; 003T653; Testosterone Propionate 1.0 mg/ml in Acetonitrile; Testosterone propionate, tested according to Ph.Eur.; W-105436; BRD-K90553655-001-03-6; Q10354588; WLN: L E5 B666 OV MUTJ A E FO52 -B&AEF; Androst-4-en-3-one, 17-(1-oxopropoxy)-(17.beta.)-; Testosterone propionate, British Pharmacopoeia (BP) Reference Standard; Testosterone propionate, European Pharmacopoeia (EP) Reference Standard; Testosterone propionate, United States Pharmacopeia (USP) Reference Standard; (1S,3aS,3bR,9aR,9bS,11aS)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate; Propionic acid (8R,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester; Propionic acid 10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester; Propionic acid 10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl ester(Testosterone Propionate); Testosterone propionate for system suitability, European Pharmacopoeia (EP) Reference Standard
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Molecular Type
Small molecule
Disease Diminished ovarian reserve [ICD-11: 5A80] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C22H32O3
PubChem CID
5995
Canonical SMILES
CCC(=O)OC1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI
1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
InChIKey
PDMMFKSKQVNJMI-BLQWBTBKSA-N
CAS Number
CAS 57-85-2
ChEBI ID
CHEBI:9466
TTD Drug ID
D0SP7S
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Arsenic trioxide      Realgar and orpiment     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation
Down-regulation Phosphorylation AKT1  Molecule Info 
Pathway MAP
Up-regulation Expression ATG5  Molecule Info 
Pathway MAP
Down-regulation Expression BCL-2  Molecule Info 
Pathway MAP
Up-regulation Cleavage CASP3  Molecule Info 
Pathway MAP
Down-regulation Phosphorylation CYB5R2  Molecule Info 
Pathway MAP
Up-regulation Expression MAP1LC3A  Molecule Info 
Pathway MAP
Down-regulation Phosphorylation mTOR  Molecule Info 
Pathway MAP
Up-regulation Cleavage PARP1  Molecule Info 
Pathway MAP
Down-regulation Phosphorylation S6K1  Molecule Info 
Pathway MAP
Up-regulation Expression SQSTM1  Molecule Info 
Pathway MAP
                    In-vitro Model LNCaP CVCL_0395 Prostate carcinoma Homo sapiens
PC-3 CVCL_0035 Prostate carcinoma Homo sapiens
                    Experimental
                    Result(s)
Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells.
References
Reference 1 ClinicalTrials.gov (NCT03447184) Long-term Endogenous Androgen Priming in Bologna Criteria Poor Responder Patients - A Pilot Study
Reference 2 Arsenic trioxide enhances the radiation sensitivity of androgen-dependent and -independent human prostate cancer cells. PLoS One. 2012;7(2):e31579.
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Cite NPCDR
Visitor Map
Correspondence

X. N. Sun, Y. T. Zhang, Y. Zhou, X. C. Lian, L. L. Yan, T. Pan, T. Jin, H. Xie, Z. M. Liang, W. Q. Qiu, J. X. Wang, Z. R. Li, F. Zhu*, X. B. Sui*. NPCDR: natural product-based drug combination and its disease-specific molecular regulation. Nucleic Acids Research. 50(D1): 1324-1333 (2020). PMID: 34664659

Prof. Feng ZHU  (zhufeng@zju.edu.cn)

College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China


Prof. Xinbing SUI  (hzzju@hznu.edu.cn)

School of Pharmacy and Department of Medical Oncology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, China