Drug Details
| General Information of the Drug (ID: DR9093) | ||||
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| Name |
Sodium butyrate
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| Synonyms |
Butyrate sodium; Sodium butanoate; Sodium propanecarboxylate; OR8783; Butanoic acid, sodium salt; Butyric Acid, Na; Sodium butyrate (USP); Sodium n-butyrate; TPA/BA; Tetradecanoyl phorbol acetate/ sodium butyrate; Butanoic acid, sodium salt (1:1); Tetradecanoyl phorbol acetate (TPA)/ sodium butyrate (BA)
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| Molecular Type |
Small molecule
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| Disease | Acute myeloid leukemia [ICD-11: 2A60] | Phase 2 | [1] | |
| Structure |
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Click to Download Mol2D MOL |
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| Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product | ||||
| Formula |
C4H7NaO2
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| PubChem CID | ||||
| Canonical SMILES |
CCCC(=O)[O-].[Na+]
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| InChI |
1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
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| InChIKey |
MFBOGIVSZKQAPD-UHFFFAOYSA-M
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| CAS Number |
CAS 156-54-7
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| TTD Drug ID | ||||
| DrugBank ID | ||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
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| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Artemisinin | Artemisia annua | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
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| Biological
Regulation |
Up-regulation | Apoptosis | ||||
| In-vitro Model | MOLT-4 | CVCL_0013 | Adult T acute lymphoblastic leukemia | Homo sapiens | ||
| Experimental
Result(s) |
DHA in combination with butyric acid acts synergistically at low doses. | |||||
| Epigallocatechin gallate | Hamamelis virginiana | Click to Show/Hide the Molecular Data of This NP | ||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [3] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | DNMT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | HDAC1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Cell cycle arrest in G2/M phase | ||||
| In-vitro Model | RKO | CVCL_0504 | Colon carcinoma | Homo sapiens | ||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
At low and physiologically achievable concentrations, combinatorial EGCG and NaB are effective in promoting apoptosis, inducing cell cycle arrest and DNA-damage in CRC cells. | |||||
| Target and Pathway | ||||
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| Target(s) | Histone deacetylase 1 (HDAC1) | Molecule Info | [4] | |
| KEGG Pathway | Cell cycle | Click to Show/Hide | ||
| 2 | Notch signaling pathway | |||
| 3 | Thyroid hormone signaling pathway | |||
| 4 | Huntington's disease | |||
| 5 | Amphetamine addiction | |||
| 6 | Alcoholism | |||
| 7 | Epstein-Barr virus infection | |||
| 8 | Pathways in cancer | |||
| 9 | Transcriptional misregulation in cancer | |||
| 10 | Viral carcinogenesis | |||
| 11 | MicroRNAs in cancer | |||
| 12 | Chronic myeloid leukemia | |||
| NetPath Pathway | TCR Signaling Pathway | Click to Show/Hide | ||
| Panther Pathway | Wnt signaling pathway | Click to Show/Hide | ||
| 2 | p53 pathway | |||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | Click to Show/Hide | ||
| 2 | Notch signaling pathway | |||
| 3 | E2F transcription factor network | |||
| 4 | Presenilin action in Notch and Wnt signaling | |||
| 5 | Signaling events mediated by HDAC Class I | |||
| 6 | Regulation of Telomerase | |||
| 7 | Glucocorticoid receptor regulatory network | |||
| 8 | Sumoylation by RanBP2 regulates transcriptional repression | |||
| 9 | Regulation of Androgen receptor activity | |||
| 10 | IL3-mediated signaling events | |||
| 11 | Validated nuclear estrogen receptor alpha network | |||
| 12 | Retinoic acid receptors-mediated signaling | |||
| 13 | Hedgehog signaling events mediated by Gli proteins | |||
| 14 | Regulation of nuclear beta catenin signaling and target gene transcription | |||
| 15 | Validated targets of C-MYC transcriptional repression | |||
| 16 | Regulation of retinoblastoma protein | |||
| 17 | Notch-mediated HES/HEY network | |||
| Reactome | G0 and Early G1 | Click to Show/Hide | ||
| 2 | p75NTR negatively regulates cell cycle via SC1 | |||
| 3 | Formation of the beta-catenin:TCF transactivating complex | |||
| 4 | NOTCH1 Intracellular Domain Regulates Transcription | |||
| 5 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | |||
| 6 | Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||
| 7 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||
| 8 | HDACs deacetylate histones | |||
| 9 | Deactivation of the beta-catenin transactivating complex | |||
| 10 | NoRC negatively regulates rRNA expression | |||
| 11 | RNA Polymerase I Transcription Initiation | |||
| 12 | Factors involved in megakaryocyte development and platelet production | |||
| WikiPathways | SIDS Susceptibility Pathways | Click to Show/Hide | ||
| 2 | Notch Signaling Pathway | |||
| 3 | TGF beta Signaling Pathway | |||
| 4 | IL-6 signaling pathway | |||
| 5 | Apoptosis-related network due to altered Notch3 in ovarian cancer | |||
| 6 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | |||
| 7 | Notch Signaling Pathway | |||
| 8 | Retinoblastoma (RB) in Cancer | |||
| 9 | Neural Crest Differentiation | |||
| 10 | TWEAK Signaling Pathway | |||
| 11 | Integrated Breast Cancer Pathway | |||
| 12 | Signalling by NGF | |||
| 13 | RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | |||
| 14 | Mitotic G1-G1/S phases | |||
| 15 | Factors involved in megakaryocyte development and platelet production | |||
| 16 | Cell Cycle | |||
| 17 | Androgen receptor signaling pathway | |||
