Natural Product (NP) Details
| General Information of the NP (ID: NP3850) | |||||
|---|---|---|---|---|---|
| Name |
Black tea polyphenol
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| Species Origin | Camellia sinensis ... | Click to Show/Hide | |||
| Camellia sinensis | |||||
| Disease | Melanoma [ICD-11: 2C30] | Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP | ||||||
| Cisplatin | Bladder cancer | Click to Show/Hide the Molecular Data of This Drug | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
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| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP7 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Cell cycle arrest in G1/S phase | ||||
| Up-regulation | Cytochrome c release | |||||
| In-vitro Model | A2780/CP70 | CVCL_0135 | Ovarian endometrioid adenocarcinoma | Homo sapiens | ||
| OVCAR-3 | CVCL_0465 | Ovarian serous adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Combination treatment showed a synergistic pro-apoptotic effect and synergistically induced G1/S phase cell cycle arrest. | |||||
