Drug Combination Details
| General Information of the Combination (ID: C02521) | |||||
|---|---|---|---|---|---|
| Name | Resveratrol NP Info | + | 5-fluorouracil Drug Info | ||
| Structure |
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+ |
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| Disease |
Hepatocellular carcinoma
[ICD-11: 2C12]
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Investigative | [1] | ||
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Skin cancer
[ICD-11: 2C30-2C37]
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Investigative | [2] | |||
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Melanoma
[ICD-11: 2C30]
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Investigative | [3] | |||
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Colorectal cancer
[ICD-11: 2B91]
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Investigative | [4] | |||
| Click to Show/Hide the Whole Disease Information of This Combination | |||||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [4] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDH1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | p105 | Molecule Info |
Pathway MAP
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| In-vitro Model | SW480 | CVCL_0546 | Colon adenocarcinoma | Homo sapiens | ||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. | |||||
| Experiment 2 Reporting the Effect of This Combination | [5] | |||||
| Molecule(s)
Regulation |
Up-regulation | Cleavage | CASP6 | Molecule Info |
Pathway MAP
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| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| Experimental
Result(s) |
RSV synergistically promotes 5-FU-mediated apoptosis at its higher concentration irrespective of p53. Conversely, it inhibits 5-FU-triggered apoptosis at lower concentrations in p53+/+ cells. | |||||
| Experiment 3 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | COX-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Phosphorylation | PRKAA1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VASP | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | VEGFA | Molecule Info |
Pathway MAP
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| In-vitro Model | B16 | CVCL_F936 | Mouse melanoma | Mus musculus | ||
| In-vivo Model | The B16 murine melanoma cells (2.5*105 cells/0.1 mL) were subcutaneously injected into the left flank of male five-week-old Balb/c nu/nu mice. | |||||
| Experimental
Result(s) |
Co-treatment using resveratrol and 5-FU inhibited cell proliferation are more efficiently compared with use of either drug alone. | |||||
| Experiment 4 Reporting the Effect of This Combination | [1] | |||||
| Biological
Regulation |
Arrest | Cell cycle arrest in G2/M phase | ||||
| In-vivo Model | About 0.2 mL H22 cell solution (including 2*107 cells) was taken and injected into the right groin of Balb/c mice. | |||||
| Experimental
Result(s) |
RES could induce the S phase arrest of H22 cells and enhance the anti-tumor effect of 5-FU on murine hepatoma22 and antagonize its toxicity markedly. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [6] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | STAT3 | Molecule Info |
Pathway MAP
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| In-vitro Model | SW620 | CVCL_0547 | Colon adenocarcinoma | Homo sapiens | ||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Combined treatment with resveratrol sensitized colon cancer cells to 5-fluorouracil, inducing a further increase in oxidative stress, which was linked to the inhibition of AKT and STAT3 proteins, which are known to have oncogenic potential in colorectal carcinomas. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | TP53 | Molecule Info |
Pathway MAP
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| In-vitro Model | TE-1 | CVCL_1759 | Esophageal squamous cell carcinoma | Homo sapiens | ||
| A-431 | CVCL_0037 | Skin squamous cell carcinoma | Homo sapiens | |||
| In-vivo Model | The topical use of 7, 12-dimethylbenz[a]anthracene (DMBA) in acetone (150 mg/mouse) served as a tumor initiator in swiss albino mice. | |||||
| Experimental
Result(s) |
Resveratrol synergistically augments anti-tumor effect of 5-FU in vitro and in vivo by increasing S-phase arrest and tumor apoptosis. | |||||
