Drug Combination Details
| General Information of the Combination (ID: C44725) | |||||
|---|---|---|---|---|---|
| Name | Flavopiridol NP Info | + | Gemcitabine Drug Info | ||
| Structure |
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+ |
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| Disease |
Solid tumour/cancer
[ICD-11: 2A00-2F9Z]
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Phase 1 | [1] | ||
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Malignant digestive organ neoplasm
[ICD-11: 2C11]
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Investigative | [2] | |||
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Breast cancer
[ICD-11: 2C60]
|
Investigative | [3] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [3] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CDKN1A | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | MCF-7 | CVCL_0031 | Invasive breast carcinoma | Homo sapiens | ||
| MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
A sequence dependent potentiation of the effect of gemcitabine by flavopiridol was demonstrated in breast cancer cell lines and it was independent of ER status. This was accompanied by enhanced apoptosis and the up regulation of p21(WAF-1) protein. | |||||
| Experiment 2 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | E2F1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | RRM2 | Molecule Info |
Pathway MAP
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| In-vitro Model | MKN74 | CVCL_2791 | Gastric tubular adenocarcinoma | Homo sapiens | ||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| Capan-2 | CVCL_0026 | Pancreatic ductal adenocarcinoma | Homo sapiens | |||
| SK-GT-5 | CVCL_8114 | Gastric adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit (RR-M2). | |||||
