Drug Combination Details
| General Information of the Combination (ID: C56521) | |||||
|---|---|---|---|---|---|
| Name | Curcumin NP Info | + | Tolfenamic acid Drug Info | ||
| Structure |
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+ |
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| Disease |
Colon cancer
[ICD-11: 2B90]
|
Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BIRC5 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Activity | CASP7 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PSG1 | Molecule Info | |||
| Biological
Regulation |
Induction | Loss of mitochondrial membrane potential | ||||
| Up-regulation | ROS generation | |||||
| In-vitro Model | HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | ||
| HT-29 | CVCL_0320 | Colon adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Thioridazine plus curcumin induces proteasome activity by up-regulating PSMA5 expression via NOX4-mediated ROS production and that down-regulation of c-FLIP and Mcl-1 expression post-translationally is involved in apoptosis. | |||||
