Drug Combination Details
| General Information of the Combination (ID: C69797) | |||||
|---|---|---|---|---|---|
| Name | Eugenol NP Info | + | Cisplatin Drug Info | ||
| Structure |
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+ |
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| Disease |
Breast cancer
[ICD-11: 2C60]
|
Investigative | [1] | ||
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Ovarian cancer
[ICD-11: 2C73]
|
Investigative | [2] | |||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [2] | |||||
| Molecule(s)
Regulation |
Down-regulation | Phosphorylation | AKT1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | CD44 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | HES1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | HEY1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MYC | Molecule Info |
Pathway MAP
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| Down-regulation | Cleavage | NOTCH1 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | SK-OV-3 | CVCL_0532 | Ovarian serous cystadenocarcinoma | Homo sapiens | ||
| MDAH 2774 | CVCL_0420 | Ovarian endometrioid adenocarcinoma | Homo sapiens | |||
| Experimental
Result(s) |
Sequential combination of cisplatin with eugenol targets ovarian cancer stem cells through the Notch-Hes1 signalling pathway. | |||||
| Augmenting Drug Sensitivity | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP3 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | CASP9 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | p105 | Molecule Info |
Pathway MAP
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| Up-regulation | Cleavage | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Phosphorylation | RELA | Molecule Info |
Pathway MAP
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| In-vitro Model | MDA-MB-231 | CVCL_0062 | Breast adenocarcinoma | Homo sapiens | ||
| MDA-MB-468 | CVCL_0419 | Breast adenocarcinoma | Homo sapiens | |||
| BT-20 | CVCL_0178 | Invasive breast carcinoma | Homo sapiens | |||
| In-vivo Model | Breast cancer xenografts were created 4-6week female nude mice by subcutaneous injection of the MDA-MB-231 cells (5*106) into the right leg of each mouse. | |||||
| Experimental
Result(s) |
Eugenol potentiates cisplatin anti-cancer activity through inhibition of ALDH-positive breast cancer stem cells and the NF-kappaB signaling pathway. | |||||
