Drug Combination Details
| General Information of the Combination (ID: C94552) | |||||
|---|---|---|---|---|---|
| Name | Vincristine NP Info | + | Vorinostat Drug Info | ||
| Structure |
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| Disease |
Anaplastic large cell lymphoma
[ICD-11: 2A90]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | HDAC6 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| Biological
Regulation |
Induction | Cell cycle arrest in G2/M phase | ||||
| In-vitro Model | MOLT-4 | CVCL_0013 | Adult T acute lymphoblastic leukemia | Homo sapiens | ||
| CCRF-CEM | CVCL_0207 | T acute lymphoblastic leukemia | Homo sapiens | |||
| In-vivo Model | MOLT-4 cells were implanted (1*107 cells/ml) into severe combined immunodeficiency (SCID) mice. | |||||
| Experimental
Result(s) |
The combination of vincristine and SAHA on T cell leukemic cells resulted in a change in microtubule dynamics contributing to M phase arrest followed by induction of the apoptotic pathway. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo. J Hematol Oncol. 2015 Jul 10;8:82. | |||
