Drug Details
| General Information of the Drug (ID: DR0767) | ||||
|---|---|---|---|---|
| Name |
Vasostatin
|
|||
| Disease | Pancreatic endocrine tumor [ICD-11: 2E92] | Phase 4 | [1] | |
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug | ||||||
| Triptolide | Tripterygium hypoglaucum | Click to Show/Hide the Molecular Data of This NP | ||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Representative Experiment Reporting the Effect of This Combination | [2] | |||||
| Detail(s) |
Combination Info
click to show the detail info of this combination
|
|||||
| Molecule(s)
Regulation |
Up-regulation | Expression | BAD | Molecule Info |
Pathway MAP
|
|
| Up-regulation | Expression | BAK | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | BAX | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | BCL-2 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | BCL-xL | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | BIRC2 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | CASP3 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | CASP8 | Molecule Info |
Pathway MAP
|
||
| Up-regulation | Expression | CASP9 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | CFLAR | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | MCL1 | Molecule Info |
Pathway MAP
|
||
| Down-regulation | Expression | p105 | Molecule Info |
Pathway MAP
|
||
| In-vitro Model | A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | ||
| HCT 116 | CVCL_0291 | Colon carcinoma | Homo sapiens | |||
| HEK293 | CVCL_0045 | Healthy | Homo sapiens | |||
| QSG-7701 | CVCL_6944 | Human hepatocarcinoma | Homo sapiens | |||
| HUVEC | CVCL_2959 | Healthy | Homo sapiens | |||
| In-vivo Model | HCT116 cells in a solution containing 25 ml of culture medium and 25 ml of mouse sarcoma extracellular matrix (Matrigel) were injected subcutaneously into the dorsal flanks of mice. | |||||
| Experimental
Result(s) |
Herbal compound triptolide synergistically enhanced antitumor activity of vasostatin120-180. | |||||
| Target and Pathway | ||||
|---|---|---|---|---|
| Target(s) | Retinoic acid receptor alpha (RARA) | Molecule Info | [3] | |
| Retinoic acid receptor beta (RARB) | Molecule Info | [3] | ||
| KEGG Pathway | Pathways in cancer | Click to Show/Hide | ||
| 2 | Small cell lung cancer | |||
| 3 | Non-small cell lung cancer | |||
| 4 | Transcriptional misregulation in cancer | |||
| 5 | Acute myeloid leukemia | |||
| Pathway Interaction Database | Retinoic acid receptors-mediated signaling | Click to Show/Hide | ||
| Reactome | Nuclear Receptor transcription pathway | Click to Show/Hide | ||
| WikiPathways | Vitamin A and Carotenoid Metabolism | Click to Show/Hide | ||
| 2 | Nuclear Receptors in Lipid Metabolism and Toxicity | |||
| 3 | Mesodermal Commitment Pathway | |||
| 4 | Integrated Pancreatic Cancer Pathway | |||
| 5 | Nuclear Receptors | |||
| 6 | Adipogenesis | |||
