Drug Details

General Information of the Drug (ID: DR1130)
Name
PD184352
Synonyms
212631-79-3; CI-1040; PD184352; PD 184352; PD-184352; 2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; PD184352 (CI-1040); CI 1040; CI1040; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide; 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; PD-18435; UNII-R3K9Y00J04; C.I. 1040; CHEMBL105442; R3K9Y00J04; MFCD02683961; NCGC00189074-01; CI-1040 (PD184352); DSSTox_CID_28871; DSSTox_RID_83140; DSSTox_GSID_48945; C17H14ClF2IN2O2; CAS-212631-79-3; PD 184,352; cc-384; MLS006010176; SCHEMBL570330; PD 184352, Free Base; GTPL5676; QCR-25; DTXSID8048945; CHEBI:91353; SYN1031; HMS3244G05; HMS3244G06; HMS3244H05; HMS3265I07; HMS3265I08; HMS3265J07; HMS3265J08; HMS3654I05; AOB87195; BCP01791; EX-A2202; ZINC1489691; Tox21_113363; ABP000919; BDBM50132260; NSC765695; s1020; 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide; AKOS022184333; Tox21_113363_1; CCG-269529; CS-0058; DB12429; NSC-765695; SB19417; 2-[(2-CHLORO-4-IODOPHENYL)AMINO]-N-(CYCLOPROPYLMETHOXY)-3,4-DIFLUOROBENZAMIDE; NCGC00189074-03; NCGC00189074-05; AC-25483; AS-19373; HY-50295; SMR004701284; CI-1040,PD184352; PD 184352CI-1040; AB0033705; DB-014962; CI-1040; PD184352; FT-0673543; SW219604-1; X7396; EC-000.2331; PD 184352(CI-1040); PD184352 - CI-1040; A25744; PD184352, >=98% (HPLC); S-7729; CI-1040/CI1040,PD184352; 631C793; US8575391, 341; J-505572; BRD-K05104363-001-01-9; Q27076005; 4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 2-(2-Chloro4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide; 2-[(2-Chloro-4-iodophenyl)amino]-N-cyclopropylmethoxy)-3,4-difluorobenzamide; Benzamide, 2-((2-chloro-4-iodophenyl)amino)-N-(cyclopropylmethoxy)-3,4-difluoro-; CI-1040; ; ; 2-(2-Chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide
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Molecular Type
Small molecule
Disease Chronic lymphocytic leukaemia [ICD-11: 2A82] Investigative [1]
Structure
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2D MOL

3D MOL

    Click to Show/Hide the Molecular Information and External Link(s) of This Natural Product
Formula
C17H14ClF2IN2O2
PubChem CID
6918454
Canonical SMILES
C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl
InChI
1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)
InChIKey
GFMMXOIFOQCCGU-UHFFFAOYSA-N
CAS Number
CAS 212631-79-3
ChEBI ID
CHEBI:91353
TTD Drug ID
D0B9BU
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Natural Product(s) Able to Enhance the Efficacy of This Drug
          Arsenic trioxide      Realgar and orpiment     Click to Show/Hide the Molecular Data of This NP
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Expression BAX  Molecule Info 
Pathway MAP
Down-regulation Phosphorylation ERK1  Molecule Info 
Pathway MAP
Up-regulation Cleavage PARP1  Molecule Info 
Pathway MAP
                    Biological
                    Regulation		 Increase Mitochondrial transmembrane potential
Increase Percentage of sub-G1 apoptotic cells
                    In-vitro Model NB4 CVCL_0005 Acute promyelocytic leukemia Homo sapiens
Acute promyelocytic leukemia primary blasts derived from patients Acute promyelocytic leukemia Homo sapiens
                    Experimental
                    Result(s)		 Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells.
Target and Pathway
Target(s) Checkpoint kinase-1 (CHK1)  Molecule Info  [3]
Extracellular signal-regulated kinase 2 (ERK2)  Molecule Info  [3]
Glycogen synthase kinase-3 beta (GSK-3B)  Molecule Info  [3]
LCK tyrosine protein kinase (LCK)  Molecule Info  [3]
MAPK/ERK kinase kinase 1 (MAP3K1)  Molecule Info  [4]
MAPK/ERK kinase kinase 2 (MAP3K2)  Molecule Info  [4]
Protein kinase B alpha (AKT1)  Molecule Info  [3]
Protein kinase C alpha (PRKCA)  Molecule Info  [3]
Rho-associated protein kinase 1 (ROCK1)  Molecule Info  [3]
Ribosomal protein S6 kinase beta-1 (S6K1)  Molecule Info  [3]
Serine/threonine-protein kinase Sgk1 (SGK1)  Molecule Info  [3]
Stress-activated protein kinase 2a (SAPK2A)  Molecule Info  [3]
Stress-activated protein kinase 2b (SAPK2B)  Molecule Info  [3]
Stress-activated protein kinase 3 (SAPK3)  Molecule Info  [3]
Stress-activated protein kinase JNK1 (JNK1)  Molecule Info  [3]
KEGG Pathway MAPK signaling pathway Click to Show/Hide
2 Ubiquitin mediated proteolysis
3 RIG-I-like receptor signaling pathway
4 Neurotrophin signaling pathway
5 GnRH signaling pathway
6 Hepatitis B
7 HTLV-I infection
8 Gap junction
9 FoxO signaling pathway
10 PI3K-Akt signaling pathway
11 Aldosterone-regulated sodium reabsorption
12 ErbB signaling pathway
13 Ras signaling pathway
14 Rap1 signaling pathway
15 cGMP-PKG signaling pathway
16 cAMP signaling pathway
17 Chemokine signaling pathway
18 HIF-1 signaling pathway
19 Sphingolipid signaling pathway
20 Oocyte meiosis
21 mTOR signaling pathway
22 Adrenergic signaling in cardiomyocytes
23 Vascular smooth muscle contraction
24 Dorso-ventral axis formation
25 TGF-beta signaling pathway
26 Axon guidance
27 VEGF signaling pathway
28 Osteoclast differentiation
29 Focal adhesion
30 Adherens junction
31 Signaling pathways regulating pluripotency of stem cells
32 Platelet activation
33 Toll-like receptor signaling pathway
34 NOD-like receptor signaling pathway
35 Natural killer cell mediated cytotoxicity
36 T cell receptor signaling pathway
37 B cell receptor signaling pathway
38 Fc epsilon RI signaling pathway
39 Fc gamma R-mediated phagocytosis
40 TNF signaling pathway
41 Circadian entrainment
42 Long-term potentiation
43 Retrograde endocannabinoid signaling
44 Glutamatergic synapse
45 Cholinergic synapse
46 Serotonergic synapse
47 Long-term depression
48 Regulation of actin cytoskeleton
49 Insulin signaling pathway
50 Progesterone-mediated oocyte maturation
51 Estrogen signaling pathway
52 Melanogenesis
53 Prolactin signaling pathway
54 Thyroid hormone signaling pathway
55 Oxytocin signaling pathway
56 Type II diabetes mellitus
57 Alzheimer's disease
58 Prion diseases
59 Alcoholism
60 Shigellosis
61 Salmonella infection
62 Pertussis
63 Leishmaniasis
64 Chagas disease (American trypanosomiasis)
65 Toxoplasmosis
66 Tuberculosis
67 Hepatitis C
68 Influenza A
69 Pathways in cancer
70 Viral carcinogenesis
71 Proteoglycans in cancer
72 MicroRNAs in cancer
73 Colorectal cancer
74 Renal cell carcinoma
75 Pancreatic cancer
76 Endometrial cancer
77 Glioma
78 Prostate cancer
79 Thyroid cancer
80 Melanoma
81 Bladder cancer
82 Chronic myeloid leukemia
83 Acute myeloid leukemia
84 Non-small cell lung cancer
85 Central carbon metabolism in cancer
86 Choline metabolism in cancer
87 AMPK signaling pathway
88 Leukocyte transendothelial migration
89 Pathogenic Escherichia coli infection
90 Protein processing in endoplasmic reticulum
91 Wnt signaling pathway
92 Dopaminergic synapse
93 Inflammatory mediator regulation of TRP channels
94 Adipocytokine signaling pathway
95 Non-alcoholic fatty liver disease (NAFLD)
96 Epithelial cell signaling in Helicobacter pylori infection
97 Herpes simplex infection
98 Epstein-Barr virus infection
99 Calcium signaling pathway
100 Phosphatidylinositol signaling system
101 Tight junction
102 GABAergic synapse
103 Insulin secretion
104 Thyroid hormone synthesis
105 Endocrine and other factor-regulated calcium reabsorption
106 Salivary secretion
107 Gastric acid secretion
108 Pancreatic secretion
109 Amphetamine addiction
110 Morphine addiction
111 Vibrio cholerae infection
112 African trypanosomiasis
113 Amoebiasis
114 Amyotrophic lateral sclerosis (ALS)
115 NF-kappa B signaling pathway
116 Primary immunodeficiency
117 Cell cycle
118 p53 signaling pathway
119 Hedgehog signaling pathway
120 Hippo signaling pathway
121 Measles
122 Basal cell carcinoma
123 Apoptosis
124 Jak-STAT signaling pathway
125 Glucagon signaling pathway
126 Regulation of lipolysis in adipocytes
127 Carbohydrate digestion and absorption
128 Small cell lung cancer
NetPath Pathway IL5 Signaling Pathway Click to Show/Hide
2 TGF_beta_Receptor Signaling Pathway
3 TCR Signaling Pathway
4 FSH Signaling Pathway
5 IL2 Signaling Pathway
6 TNFalpha Signaling Pathway
7 TSH Signaling Pathway
Panther Pathway Angiogenesis Click to Show/Hide
2 Apoptosis signaling pathway
3 T cell activation
4 Ras Pathway
5 B cell activation
6 EGF receptor signaling pathway
7 FGF signaling pathway
8 Alzheimer disease-amyloid secretase pathway
9 Endothelin signaling pathway
10 Inflammation mediated by chemokine and cytokine signaling pathway
11 Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
12 Interferon-gamma signaling pathway
13 Interleukin signaling pathway
14 PDGF signaling pathway
15 Parkinson disease
16 TGF-beta signaling pathway
17 VEGF signaling pathway
18 Angiotensin II-stimulated signaling through G proteins and beta-arrestin
19 CCKR signaling map ST
20 PI3 kinase pathway
21 p53 pathway by glucose deprivation
22 Cytoskeletal regulation by Rho GTPase
23 FAS signaling pathway
24 Integrin signalling pathway
25 Oxidative stress response
26 Toll receptor signaling pathway
27 Alpha adrenergic receptor signaling pathway
28 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
29 Muscarinic acetylcholine receptor 1 and 3 signaling pathway
30 Wnt signaling pathway
31 5HT2 type receptor mediated signaling pathway
32 Histamine H1 receptor mediated signaling pathway
33 Oxytocin receptor mediated signaling pathway
34 Thyrotropin-releasing hormone receptor signaling pathway
35 p53 pathway feedback loops 2
36 p38 MAPK pathway
37 Alzheimer disease-presenilin pathway
38 Cadherin signaling pathway
39 Hedgehog signaling pathway
40 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
41 Insulin/IGF pathway-protein kinase B signaling cascade
42 Huntington disease
43 Hypoxia response via HIF activation
44 p53 pathway
Pathwhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Click to Show/Hide
2 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
3 Fc Epsilon Receptor I Signaling in Mast Cells
4 Insulin Signalling
5 Leucine Stimulation on Insulin Signaling
6 Activation of PKC through G protein coupled receptor
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells Click to Show/Hide
2 BCR signaling pathway
3 p38 MAPK signaling pathway
4 CD40/CD40L signaling
5 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
6 Osteopontin-mediated events
7 TRAIL signaling pathway
8 CDC42 signaling events
9 FAS (CD95) signaling pathway
10 Role of Calcineurin-dependent NFAT signaling in lymphocytes
11 TNF receptor signaling pathway
12 Ceramide signaling pathway
13 IFN-gamma pathway
14 ErbB1 downstream signaling
15 JNK signaling in the CD4+ TCR pathway
16 Caspase Cascade in Apoptosis
17 Regulation of cytoplasmic and nuclear SMAD2/3 signaling
18 RAC1 signaling pathway
19 Trk receptor signaling mediated by the MAPK pathway
20 Insulin Pathway
21 Glucocorticoid receptor regulatory network
22 mTOR signaling pathway
23 FoxO family signaling
24 Class I PI3K signaling events
25 Endothelins
26 Signaling events mediated by PRL
27 ErbB4 signaling events
28 GMCSF-mediated signaling events
29 S1P3 pathway
30 EPHB forward signaling
31 S1P4 pathway
32 Presenilin action in Notch and Wnt signaling
33 Signaling events regulated by Ret tyrosine kinase
34 Angiopoietin receptor Tie2-mediated signaling
35 S1P1 pathway
36 Regulation of Telomerase
37 Netrin-mediated signaling events
38 Arf6 downstream pathway
39 Class IB PI3K non-lipid kinase events
40 IL2-mediated signaling events
41 EGF receptor (ErbB1) signaling pathway
42 Ras signaling in the CD4+ TCR pathway
43 Integrins in angiogenesis
44 ATF-2 transcription factor network
45 ErbB2/ErbB3 signaling events
46 BMP receptor signaling
47 ALK1 signaling events
48 PDGFR-beta signaling pathway
49 Neurotrophic factor-mediated Trk receptor signaling
50 Syndecan-1-mediated signaling events
51 Retinoic acid receptors-mediated signaling
52 Nongenotropic Androgen signaling
53 CXCR3-mediated signaling events
54 VEGFR1 specific signals
55 Signaling events mediated by VEGFR1 and VEGFR2
56 Syndecan-2-mediated signaling events
57 Cellular roles of Anthrax toxin
58 S1P2 pathway
59 Downstream signaling in na&#xef
60
61 VEGFR3 signaling in lymphatic endothelium
62 Alpha-synuclein signaling
63 FGF signaling pathway
64 Signaling events mediated by focal adhesion kinase
65 IL4-mediated signaling events
66 IGF1 pathway
67 IL2 signaling events mediated by PI3K
68 RXR and RAR heterodimerization with other nuclear receptor
69 Signaling events mediated by Stem cell factor receptor (c-Kit)
70 a6b1 and a6b4 Integrin signaling
71 TGF-beta receptor signaling
72 RhoA signaling pathway
73 Noncanonical Wnt signaling pathway
74 Thromboxane A2 receptor signaling
75 PAR4-mediated thrombin signaling events
76 amb2 Integrin signaling
77 EPHA forward signaling
78 Stabilization and expansion of the E-cadherin adherens junction
79 PAR1-mediated thrombin signaling events
80 N-cadherin signaling events
81 Reelin signaling pathway
82 IL1-mediated signaling events
83 Rapid glucocorticoid signaling
84 Regulation of Androgen receptor activity
85 p75(NTR)-mediated signaling
86 Nephrin/Neph1 signaling in the kidney podocyte
87 HIV-1 Nef: Negative effector of Fas and TNF-alpha
88 EPO signaling pathway
89 Ephrin B reverse signaling
90 p53 pathway
91 Glypican 3 network
92 IL12 signaling mediated by STAT4
93 TCR signaling in na&#xef
94
95 Canonical NF-kappaB pathway
96 TCR signaling in na&#xef
97 Syndecan-4-mediated signaling events
98 IL8- and CXCR2-mediated signaling events
99 IL8- and CXCR1-mediated signaling events
100 Regulation of Ras family activation
101 p73 transcription factor network
102 Plasma membrane estrogen receptor signaling
103 Regulation of p38-alpha and p38-beta
104 IL6-mediated signaling events
105 p38 signaling mediated by MAPKAP kinases
106 Signaling mediated by p38-alpha and p38-beta
107 Regulation of retinoblastoma protein
108 Atypical NF-kappaB pathway
109 IL12-mediated signaling events
110 Glypican 1 network
111 Signaling events mediated by PTP1B
112 SHP2 signaling
113 CXCR4-mediated signaling events
114 IL2 signaling events mediated by STAT5
115 Fanconi anemia pathway
116 ATR signaling pathway
117 Circadian rhythm pathway
118 Signaling mediated by p38-gamma and p38-delta
119 LPA receptor mediated events
120 Degradation of beta catenin
121 Integrin-linked kinase signaling
122 LKB1 signaling events
123 Canonical Wnt signaling pathway
124 C-MYC pathway
125 Hedgehog signaling events mediated by Gli proteins
126 Validated transcriptional targets of deltaNp63 isoforms
127 Aurora A signaling
128 Insulin-mediated glucose transport
129 Class I PI3K signaling events mediated by Akt
130 Trk receptor signaling mediated by PI3K and PLC-gamma
131 Regulation of nuclear SMAD2/3 signaling
132 Coregulation of Androgen receptor activity
133 FOXA2 and FOXA3 transcription factor networks
134 E-cadherin signaling in the nascent adherens junction
135 E-cadherin signaling in keratinocytes
136 Signaling events mediated by the Hedgehog family
137 HIF-1-alpha transcription factor network
Reactome MyD88:Mal cascade initiated on plasma membrane Click to Show/Hide
2 FCERI mediated MAPK activation
3 TRAF6 mediated NF-kB activation
4 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
5 MyD88 cascade initiated on plasma membrane
6 Stimuli-sensing channels
7 RAF-independent MAPK1/3 activation
8 MAPK1 (ERK2) activation
9 Golgi Cisternae Pericentriolar Stack Reorganization
10 ERK/MAPK targets
11 Regulation of actin dynamics for phagocytic cup formation
12 Oxidative Stress Induced Senescence
13 Senescence-Associated Secretory Phenotype (SASP)
14 Oncogene Induced Senescence
15 Regulation of HSF1-mediated heat shock response
16 NCAM signaling for neurite out-growth
17 Recycling pathway of L1
18 CREB phosphorylation through the activation of Ras
19 Activation of the AP-1 family of transcription factors
20 Thrombin signalling through proteinase activated receptors (PARs)
21 Negative regulation of FGFR1 signaling
22 Negative regulation of FGFR2 signaling
23 Negative regulation of FGFR3 signaling
24 Negative regulation of FGFR4 signaling
25 RHO GTPases Activate WASPs and WAVEs
26 RAF/MAP kinase cascade
27 MAP2K and MAPK activation
28 Negative feedback regulation of MAPK pathway
29 Negative regulation of MAPK pathway
30 Signal attenuation
31 Advanced glycosylation endproduct receptor signaling
32 Gastrin-CREB signalling pathway via PKC and MAPK
33 Growth hormone receptor signaling
34 mTORC1-mediated signalling
35 Apoptotic cleavage of cellular proteins
36 EPHB-mediated forward signaling
37 EPHA-mediated growth cone collapse
38 G alpha (12/13) signalling events
39 Sema4D induced cell migration and growth-cone collapse
40 VEGFA-VEGFR2 Pathway
41 RHO GTPases Activate ROCKs
42 NRAGE signals death through JNK
43 NRIF signals cell death from the nucleus
44 DSCAM interactions
45 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
46 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
47 Calmodulin induced events
48 Disinhibition of SNARE formation
49 Regulation of KIT signaling
50 EGFR Transactivation by Gastrin
51 Inactivation, recovery and regulation of the phototransduction cascade
52 Syndecan interactions
53 Acetylcholine regulates insulin secretion
54 Ca2+ pathway
55 Trafficking of GluR2-containing AMPA receptors
56 G alpha (z) signalling events
57 Depolymerisation of the Nuclear Lamina
58 HuR (ELAVL1) binds and stabilizes mRNA
59 WNT5A-dependent internalization of FZD4
60 VEGFR2 mediated cell proliferation
61 Response to elevated platelet cytosolic Ca2+
62 NOD1/2 Signaling Pathway
63 p38MAPK events
64 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
65 CDO in myogenesis
66 activated TAK1 mediates p38 MAPK activation
67 KSRP (KHSRP) binds and destabilizes mRNA
68 ADP signalling through P2Y purinoceptor 1
69 Platelet sensitization by LDL
70 GPVI-mediated activation cascade
71 PIP3 activates AKT signaling
72 Phosphorylation of CD3 and TCR zeta chains
73 Translocation of ZAP-70 to Immunological synapse
74 Generation of second messenger molecules
75 PECAM1 interactions
76 Constitutive Signaling by Aberrant PI3K in Cancer
77 DAP12 signaling
78 CD28 co-stimulation
79 CD28 dependent PI3K/Akt signaling
80 CD28 dependent Vav1 pathway
81 CTLA4 inhibitory signaling
82 PD-1 signaling
83 Interleukin-2 signaling
84 Activation of ATR in response to replication stress
85 Processing of DNA double-strand break ends
86 Presynaptic phase of homologous DNA pairing and strand exchange
87 G2/M DNA damage checkpoint
88 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
89 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
90 Degradation of beta-catenin by the destruction complex
91 AKT phosphorylates targets in the cytosol
92 CRMPs in Sema3A signaling
93 Disassembly of the destruction complex and recruitment of AXIN to the membrane
94 S33 mutants of beta-catenin aren't phosphorylated
95 S37 mutants of beta-catenin aren't phosphorylated
96 S45 mutants of beta-catenin aren't phosphorylated
97 T41 mutants of beta-catenin aren't phosphorylated
98 Degradation of GLI2 by the proteasome
99 Constitutive Signaling by AKT1 E17K in Cancer
100 Activation of BAD and translocation to mitochondria
101 Translocation of GLUT4 to the plasma membrane
102 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
103 AKT phosphorylates targets in the nucleus
104 Negative regulation of the PI3K/AKT network
105 eNOS activation
106 AKT-mediated inactivation of FOXO1A
107 Integrin alphaIIb beta3 signaling
108 Deactivation of the beta-catenin transactivating complex
109 G beta:gamma signalling through PI3Kgamma
110 VEGFR2 mediated vascular permeability
111 TP53 Regulates Metabolic Genes
WikiPathways Serotonin HTR1 Group and FOS Pathway Click to Show/Hide
2 DNA Damage Response (only ATM dependent)
3 Interferon type I signaling pathways
4 Insulin Signaling
5 EGF/EGFR Signaling Pathway
6 MAPK Cascade
7 p38 MAPK Signaling Pathway
8 Apoptosis Modulation by HSP70
9 MAPK Signaling Pathway
10 FAS pathway and Stress induction of HSP regulation
11 MyD88 cascade initiated on plasma membrane
12 Cardiac Hypertrophic Response
13 MyD88 dependent cascade initiated on endosome
14 MyD88:Mal cascade initiated on plasma membrane
15 Fc epsilon receptor (FCERI) signaling
16 Structural Pathway of Interleukin 1 (IL-1)
17 Polycystic Kidney Disease Pathway
18 Apoptosis
19 PDGF Pathway
20 BDNF signaling pathway
21 TNF alpha Signaling Pathway
22 IL-1 signaling pathway
23 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
24 Iron uptake and transport
25 FSH signaling pathway
26 Toll-like receptor signaling pathway
27 Serotonin Receptor 4/6/7 and NR3C Signaling
28 Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
29 Vitamin A and Carotenoid Metabolism
30 TCR Signaling Pathway
31 ErbB Signaling Pathway
32 Hypothetical Network for Drug Addiction
33 Senescence and Autophagy in Cancer
34 EPO Receptor Signaling
35 Regulation of Actin Cytoskeleton
36 IL-2 Signaling Pathway
37 IL-4 Signaling Pathway
38 TGF beta Signaling Pathway
39 IL-6 signaling pathway
40 Signaling of Hepatocyte Growth Factor Receptor
41 Kit receptor signaling pathway
42 TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
43 Apoptosis-related network due to altered Notch3 in ovarian cancer
44 IL-3 Signaling Pathway
45 Bladder Cancer
46 MAP kinase activation in TLR cascade
47 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
48 RAF/MAP kinase cascade
49 Nanoparticle-mediated activation of receptor signaling
50 Genes and (Common) Pathways Underlying Drug Addiction
51 EBV LMP1 signaling
52 Signal Transduction of S1P Receptor
53 Nifedipine Activity
54 Aryl Hydrocarbon Receptor
55 Alpha 6 Beta 4 signaling pathway
56 Spinal Cord Injury
57 Integrated Pancreatic Cancer Pathway
58 Oncostatin M Signaling Pathway
59 Corticotropin-releasing hormone
60 Interleukin-11 Signaling Pathway
61 AGE/RAGE pathway
62 B Cell Receptor Signaling Pathway
63 Prostate Cancer
64 Signaling Pathways in Glioblastoma
65 TSLP Signaling Pathway
66 IL-9 Signaling Pathway
67 Endothelin Pathways
68 IL17 signaling pathway
69 Alzheimers Disease
70 IL-7 Signaling Pathway
71 TWEAK Signaling Pathway
72 Leptin signaling pathway
73 RANKL/RANK Signaling Pathway
74 Integrated Breast Cancer Pathway
75 Opioid Signalling
76 Thrombin signalling through proteinase activated receptors (PARs)
77 Signaling by FGFR
78 Integrin-mediated Cell Adhesion
79 L1CAM interactions
80 Advanced glycosylation endproduct receptor signaling
81 Heart Development
82 Type II diabetes mellitus
83 MicroRNAs in cardiomyocyte hypertrophy
84 Angiogenesis
85 Physiological and Pathological Hypertrophy of the Heart
86 Regulation of toll-like receptor signaling pathway
87 Osteopontin Signaling
88 IL-5 Signaling Pathway
89 G13 Signaling Pathway
90 Cytoplasmic Ribosomal Proteins
91 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
92 TSH signaling pathway
93 Signaling by Insulin receptor
94 TOR Signaling
95 AMPK Signaling
96 Focal Adhesion
97 JAK/STAT
98 Pathogenic Escherichia coli infection
99 Regulation of Microtubule Cytoskeleton
100 Semaphorin interactions
101 GPCR downstream signaling
102 Apoptotic execution phase
103 Androgen receptor signaling pathway
104 Transcriptional activation by NRF2
105 NLR Proteins
106 Nanoparticle triggered regulated necrosis
107 Signalling by NGF
108 Intrinsic Pathway for Apoptosis
109 DSCAM interactions
110 Apoptosis Modulation and Signaling
111 Osteoclast Signaling
112 Calcium Regulation in the Cardiac Cell
113 Wnt Signaling Pathway
114 Wnt Signaling Pathway and Pluripotency
115 Wnt Signaling Pathway Netpath
116 G Protein Signaling Pathways
117 Myometrial Relaxation and Contraction Pathways
118 Human Complement System
119 Syndecan interactions
120 Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
121 Signaling by SCF-KIT
122 DAG and IP3 signaling
123 Gastrin-CREB signalling pathway via PKC and MAPK
124 T-Cell Receptor and Co-stimulatory Signaling
125 miRs in Muscle Cell Differentiation
126 Response to elevated platelet cytosolic Ca2+
127 Integration of energy metabolism
128 Parkinsons Disease Pathway
129 NGF signalling via TRKA from the plasma membrane
130 Myogenesis
131 Monoamine Transport
132 Oxidative Stress
133 Amyotrophic lateral sclerosis (ALS)
134 Cardiac Progenitor Differentiation
135 miR-targeted genes in muscle cell - TarBase
136 miR-targeted genes in lymphocytes - TarBase
137 miR-targeted genes in leukocytes - TarBase
138 miR-targeted genes in epithelium - TarBase
139 Signal amplification
140 Platelet homeostasis
141 Notch Signaling Pathway
142 Inflammatory Response Pathway
143 DAP12 interactions
144 Host Interactions of HIV factors
145 PIP3 activates AKT signaling
146 TCR signaling
147 Costimulation by the CD28 family
148 DNA Damage Response
149 ATM Signaling Pathway
150 Retinoblastoma (RB) in Cancer
151 Integrated Cancer pathway
152 Cell Cycle
153 Cell Cycle Checkpoints
154 miRNA Regulation of DNA Damage Response
155 Glycogen Metabolism
156 Copper homeostasis
157 Hair Follicle Development: Induction (Part 1 of 3)
158 Degradation of beta-catenin by the destruction complex
159 Neural Crest Differentiation
160 Endochondral Ossification
161 Extracellular vesicle-mediated signaling in recipient cells
162 Translocation of GLUT4 to the Plasma Membrane
163 Primary Focal Segmental Glomerulosclerosis FSGS
164 SREBP signalling
165 Metabolism of nitric oxide
166 TFs Regulate miRNAs related to cardiac hypertrophy
References
Reference 1 Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro. J Biol Chem. 2003 Nov 21;278(47):47326-39.
Reference 2 Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells. Leukemia. 2005 Feb;19(2):234-44.
Reference 3 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
Reference 4 Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
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