Natural Product (NP) Details

General Information of the NP (ID: NP1406)
Name
Cryptotanshinone
Synonyms
Cryptotanshinone; 35825-57-1; Tanshinone c; (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl-phenanthro(1,2-b)furan-10,11-dione; Cryptotanshinon; UNII-5E9SXT166N; C19H20O3; (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g][1]benzofuran-10,11-dione; MLS001049002; 5E9SXT166N; MFCD07636810; SMR000387041; (R)-1,6,6-trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione; Phenanthro[1,2-b]furan-10,11-dione,1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (R)-; 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b]furan-10,11-dione; (-)-Cryptotanshinone; SR-01000758222; NSC686518; SPECTRUM1505812; CHEMBL187460; cid_160254; SCHEMBL5940386; BDBM57938; CHEBI:149838; Phenanthro(1,2-b)furan-10,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (R)-; HMS2269A22; BCP02909; Cryptotanshinone, >=90% (HPLC); Cryptotanshinone, >=98% (HPLC); HY-N0174; ZINC2109876; Cryptotanshinone, analytical standard; ANW-46875; s2285; AKOS015895392; BCP9000554; CCG-208561; CS-3276; DB15579; MCULE-9919031730; NSC-686518; NCGC00163650-01; NCGC00163650-02; 4733-35-1; BS-17094; NCI60_031208; BCP0726000307; N1843; W2147; 825C571; Q-100429; SR-01000758222-3; SR-01000758222-4; BRD-K33336844-001-05-3; Q27261913; Phenanthro[1,11-dione, 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl-, (1R)-; (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g]benzofuran-10,11-dione; (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g]benzofuran-10,11-quinone; (R)-(-)-1,6,6-Trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione; (R)-1,2,6,7,8,9-Hexahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione; 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione
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Species Origin Salvia miltiorrhiza ...     Click to Show/Hide
Salvia miltiorrhiza
Kingdom: Viridiplantae
Phylum: Streptophyta
Class: Magnoliopsida
Order: Lamiales
Family: Lamiaceae
Genus: Salvia
Species: Salvia miltiorrhiza
Disease Ovarian cancer [ICD-11: 2C73] Investigative [1]
Structure
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2D MOL

3D MOL

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Formula
C19H20O3
PubChem CID
160254
Canonical SMILES
CC1COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
InChI
1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChIKey
GVKKJJOMQCNPGB-JTQLQIEISA-N
CAS Number
CAS 35825-57-1
ChEBI ID
CHEBI:149838
Herb ID
HBIN021795
SymMap ID
SMIT00674
TCMSP ID
MOL007088
Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally
    α. A List of Drug(s) Whose Efficacy can be Enhanced by This NP
          Gefitinib      Lung cancer     Click to Show/Hide the Molecular Data of This Drug
                 Achieving Therapeutic Synergy     Click to Show/Hide
                    Representative Experiment Reporting the Effect of This Combination [2]
                    Detail(s)  Combination Info  click to show the detail info of this combination
                    Molecule(s)
                    Regulation		 Up-regulation Cleavage CASP3  Molecule Info 
Pathway MAP
Down-regulation Expression GABPA  Molecule Info 
Pathway MAP
Down-regulation Expression TK  Molecule Info 
Pathway MAP
                    In-vitro Model NCI-H1299 CVCL_0060 Lung large cell carcinoma Homo sapiens
NCI-H1975 CVCL_1511 Lung adenocarcinoma Homo sapiens
A-549 CVCL_0023 Lung adenocarcinoma Homo sapiens
                    In-vivo Model H1975 human lung cancer cells (5 * 107 in 1 ml) or PC9/GR human lung cancer cells (3 * 107 in 1 ml) were injected subcutaneously into the right flank of athymic BALB/c nude mice (3-4 weeks old).
                    Experimental
                    Result(s)		 Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase.
Target and Pathway
Target(s) Androgen receptor (AR)  Molecule Info  [3]
Apoptosis regulator BAX (BAX)  Molecule Info  [4]
DNA-binding factor KBF1 (p105)  Molecule Info  [5]
I-kappa-B-kinase beta (IKKB)  Molecule Info  [6]
Mothers against decapentaplegic 2 (SMAD2)  Molecule Info  [7]
NADPH oxidase 4 (NOX4)  Molecule Info  [8]
Prostaglandin G/H synthase 2 (COX-2)  Molecule Info  [4]
Protein-tyrosine phosphatase SHP-2 (PTPN11)  Molecule Info  [6]
S100 calcium-binding protein B (S100B)  Molecule Info  [9]
STAT factor 3 (STAT3)  Molecule Info  [7]
Sterol 26-hydroxylase (DNM1L)  Molecule Info  [10]
Transforming growth factor beta 1 (TGFB1)  Molecule Info  [10]
BioCyc Aspirin-triggered lipoxin biosynthesis Click to Show/Hide
2 Aspirin triggered resolvin D biosynthesis
3 C20 prostanoid biosynthesis
4 Aspirin triggered resolvin E biosynthesis
KEGG Pathway Ras signaling pathway Click to Show/Hide
2 Jak-STAT signaling pathway
3 Natural killer cell mediated cytotoxicity
4 Leukocyte transendothelial migration
5 Neurotrophin signaling pathway
6 Adipocytokine signaling pathway
7 Epithelial cell signaling in Helicobacter pylori infection
8 Herpes simplex infection
9 Proteoglycans in cancer
10 Renal cell carcinoma
11 Chronic myeloid leukemia
12 MAPK signaling pathway
13 Cytokine-cytokine receptor interaction
14 FoxO signaling pathway
15 Cell cycle
16 Endocytosis
17 TGF-beta signaling pathway
18 Osteoclast differentiation
19 Hippo signaling pathway
20 Intestinal immune network for IgA production
21 Non-alcoholic fatty liver disease (NAFLD)
22 Leishmaniasis
23 Chagas disease (American trypanosomiasis)
24 Malaria
25 Toxoplasmosis
26 Amoebiasis
27 Tuberculosis
28 Hepatitis B
29 HTLV-I infection
30 Pathways in cancer
31 Colorectal cancer
32 Pancreatic cancer
33 Inflammatory bowel disease (IBD)
34 Rheumatoid arthritis
35 Hypertrophic cardiomyopathy (HCM)
36 Dilated cardiomyopathy
37 Arachidonic acid metabolism
38 Metabolic pathways
39 NF-kappa B signaling pathway
40 VEGF signaling pathway
41 TNF signaling pathway
42 Retrograde endocannabinoid signaling
43 Serotonergic synapse
44 Ovarian steroidogenesis
45 Oxytocin signaling pathway
46 Regulation of lipolysis in adipocytes
47 Chemical carcinogenesis
48 MicroRNAs in cancer
49 Small cell lung cancer
50 Chemokine signaling pathway
51 mTOR signaling pathway
52 PI3K-Akt signaling pathway
53 Apoptosis
54 Toll-like receptor signaling pathway
55 NOD-like receptor signaling pathway
56 RIG-I-like receptor signaling pathway
57 Cytosolic DNA-sensing pathway
58 T cell receptor signaling pathway
59 B cell receptor signaling pathway
60 Insulin signaling pathway
61 Type II diabetes mellitus
62 Shigellosis
63 Hepatitis C
64 Influenza A
65 Epstein-Barr virus infection
66 Prostate cancer
67 Acute myeloid leukemia
68 HIF-1 signaling pathway
69 Signaling pathways regulating pluripotency of stem cells
70 Prolactin signaling pathway
71 Measles
72 Viral carcinogenesis
73 Oocyte meiosis
74 cAMP signaling pathway
75 Sphingolipid signaling pathway
76 Cocaine addiction
77 Salmonella infection
78 Pertussis
79 Legionellosis
80 Transcriptional misregulation in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway Click to Show/Hide
2 TCR Signaling Pathway
3 IL3 Signaling Pathway
4 TSH Signaling Pathway
5 IL1 Signaling Pathway
6 IL4 Signaling Pathway
7 IL5 Signaling Pathway
8 EGFR1 Signaling Pathway
9 AndrogenReceptor Signaling Pathway
10 FSH Signaling Pathway
11 IL2 Signaling Pathway
12 TNFalpha Signaling Pathway
13 Leptin Signaling Pathway
Panther Pathway CCKR signaling map ST Click to Show/Hide
2 Endothelin signaling pathway
3 Inflammation mediated by chemokine and cytokine signaling pathway
4 Toll receptor signaling pathway
5 Apoptosis signaling pathway
6 B cell activation
7 Interleukin signaling pathway
8 PDGF signaling pathway
9 T cell activation
10 Angiogenesis
11 EGF receptor signaling pathway
12 JAK/STAT signaling pathway
13 Ras Pathway
Pathwhiz Pathway Thyroid hormone synthesis Click to Show/Hide
2 Arachidonic Acid Metabolism
3 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
4 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells Click to Show/Hide
2 Insulin Pathway
3 GMCSF-mediated signaling events
4 TCR signaling in na&#xef
5
6 Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
7 Signaling events regulated by Ret tyrosine kinase
8 Angiopoietin receptor Tie2-mediated signaling
9 SHP2 signaling
10 IL2-mediated signaling events
11 CXCR4-mediated signaling events
12 IGF1 pathway
13 EGF receptor (ErbB1) signaling pathway
14 IL5-mediated signaling events
15 IL2 signaling events mediated by PI3K
16 Integrins in angiogenesis
17 IFN-gamma pathway
18 ErbB2/ErbB3 signaling events
19 IL3-mediated signaling events
20 IL6-mediated signaling events
21 PDGFR-beta signaling pathway
22 Neurotrophic factor-mediated Trk receptor signaling
23 VEGFR1 specific signals
24 Signaling events mediated by Stem cell factor receptor (c-Kit)
25 EPO signaling pathway
26 IL2 signaling events mediated by STAT5
27 Signaling events mediated by VEGFR1 and VEGFR2
28 N-cadherin signaling events
29 FGF signaling pathway
30 Glypican 1 network
31 IL27-mediated signaling events
32 Regulation of Telomerase
33 RXR and RAR heterodimerization with other nuclear receptor
34 AP-1 transcription factor network
35 Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
36 ALK1 signaling events
37 Syndecan-1-mediated signaling events
38 Syndecan-2-mediated signaling events
39 TGF-beta receptor signaling
40 IL12 signaling mediated by STAT4
41 Signaling events mediated by PTP1B
42 Calcineurin-regulated NFAT-dependent transcription in lymphocytes
43 S1P1 pathway
44 C-MYB transcription factor network
45 Signaling mediated by p38-alpha and p38-beta
46 Calcium signaling in the CD4+ TCR pathway
47 BCR signaling pathway
48 Atypical NF-kappaB pathway
49 Canonical NF-kappaB pathway
50 TRAIL signaling pathway
51 TCR signaling in na&#xef
52
53 FAS (CD95) signaling pathway
54 IL1-mediated signaling events
55 mTOR signaling pathway
56 TNF receptor signaling pathway
57 FoxO family signaling
58 p75(NTR)-mediated signaling
59 Validated transcriptional targets of TAp63 isoforms
60 Endogenous TLR signaling
61 IL12-mediated signaling events
62 Signaling events mediated by TCPTP
63 Signaling events mediated by HDAC Class I
64 ErbB1 downstream signaling
65 IL23-mediated signaling events
66 RAC1 signaling pathway
67 Notch-mediated HES/HEY network
68 Regulation of nuclear SMAD2/3 signaling
69 Coregulation of Androgen receptor activity
70 Regulation of Androgen receptor activity
71 Nongenotropic Androgen signaling
72 Regulation of nuclear beta catenin signaling and target gene transcription
73 FOXA1 transcription factor network
74 LPA receptor mediated events
75 CD40/CD40L signaling
76 Alternative NF-kappaB pathway
77 Osteopontin-mediated events
78 Glucocorticoid receptor regulatory network
79 Ceramide signaling pathway
80 amb2 Integrin signaling
81 HIV-1 Nef: Negative effector of Fas and TNF-alpha
Reactome Interleukin-6 signaling Click to Show/Hide
2 PI3K Cascade
3 MAPK3 (ERK1) activation
4 MAPK1 (ERK2) activation
5 GPVI-mediated activation cascade
6 Prolactin receptor signaling
7 PIP3 activates AKT signaling
8 Spry regulation of FGF signaling
9 GAB1 signalosome
10 PECAM1 interactions
11 Tie2 Signaling
12 Constitutive Signaling by Aberrant PI3K in Cancer
13 Costimulation by the CD28 family
14 CTLA4 inhibitory signaling
15 PD-1 signaling
16 Signal regulatory protein (SIRP) family interactions
17 Netrin mediated repulsion signals
18 Platelet sensitization by LDL
19 Interleukin-3, 5 and GM-CSF signaling
20 PI-3K cascade:FGFR1
21 FRS-mediated FGFR1 signaling
22 PI-3K cascade:FGFR2
23 SHC-mediated cascade:FGFR2
24 FRS-mediated FGFR2 signaling
25 FRS-mediated FGFR3 signaling
26 PI-3K cascade:FGFR3
27 FRS-mediated FGFR4 signaling
28 SHC-mediated cascade:FGFR4
29 PI-3K cascade:FGFR4
30 Negative regulation of FGFR1 signaling
31 Negative regulation of FGFR2 signaling
32 Negative regulation of FGFR3 signaling
33 Negative regulation of FGFR4 signaling
34 Regulation of IFNG signaling
35 Interferon alpha/beta signaling
36 Regulation of IFNA signaling
37 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
38 Platelet degranulation
39 Molecules associated with elastic fibres
40 TGF-beta receptor signaling activates SMADs
41 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
42 Syndecan interactions
43 ECM proteoglycans
44 SMAD2/3 Phosphorylation Motif Mutants in Cancer
45 SMAD2/3 MH2 Domain Mutants in Cancer
46 TGFBR2 Kinase Domain Mutants in Cancer
47 TGFBR1 KD Mutants in Cancer
48 TGFBR1 LBD Mutants in Cancer
49 Transcriptional regulation of white adipocyte differentiation
50 Activation of NF-kappaB in B cells
51 NOD1/2 Signaling Pathway
52 RIP-mediated NFkB activation via ZBP1
53 p75NTR recruits signalling complexes
54 NF-kB is activated and signals survival
55 FCERI mediated NF-kB activation
56 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
57 Interleukin-1 signaling
58 Regulation of TNFR1 signaling
59 TNFR1-induced NFkappaB signaling pathway
60 IKBKB deficiency causes SCID
61 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
62 IkBA variant leads to EDA-ID
63 CLEC7A (Dectin-1) signaling
64 MAP3K8 (TPL2)-dependent MAPK1/3 activation
65 TRAF6 mediated NF-kB activation
66 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
67 IRAK1 recruits IKK complex
68 IKK complex recruitment mediated by RIP1
69 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
70 Senescence-Associated Secretory Phenotype (SASP)
71 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
72 Transcriptional regulation of pluripotent stem cells
73 Growth hormone receptor signaling
74 Nuclear Receptor transcription pathway
75 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
76 Regulated proteolysis of p75NTR
77 DEx/H-box helicases activate type I IFN and inflammatory cytokines production
78 Interleukin-1 processing
79 CD209 (DC-SIGN) signaling
80 CLEC7A/inflammasome pathway
WikiPathways TCR Signaling Pathway Click to Show/Hide
2 Type II interferon signaling (IFNG)
3 Interferon type I signaling pathways
4 IL-2 Signaling Pathway
5 Insulin Signaling
6 EGF/EGFR Signaling Pathway
7 IL-4 Signaling Pathway
8 IL-6 signaling pathway
9 Signaling of Hepatocyte Growth Factor Receptor
10 Kit receptor signaling pathway
11 IL-3 Signaling Pathway
12 MyD88-independent cascade
13 Signaling by SCF-KIT
14 Interleukin-6 signaling
15 Prolactin receptor signaling
16 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
17 PIP3 activates AKT signaling
18 JAK/STAT
19 PDGF Pathway
20 Alpha 6 Beta 4 signaling pathway
21 BDNF signaling pathway
22 Oncostatin M Signaling Pathway
23 Interleukin-11 Signaling Pathway
24 B Cell Receptor Signaling Pathway
25 Prostate Cancer
26 Pilocytic astrocytoma
27 TSLP Signaling Pathway
28 Leptin signaling pathway
29 IL-1 signaling pathway
30 Signaling by PDGF
31 Signaling by FGFR
32 Signaling by EGFR
33 Signal regulatory protein (SIRP) family interactions
34 Platelet homeostasis
35 Netrin-1 signaling
36 Interleukin-3, 5 and GM-CSF signaling
37 Interferon alpha/beta signaling
38 Costimulation by the CD28 family
39 Cell surface interactions at the vascular wall
40 Heart Development
41 IL-5 Signaling Pathway
42 DNA Damage Response (only ATM dependent)
43 Senescence and Autophagy in Cancer
44 TGF Beta Signaling Pathway
45 ACE Inhibitor Pathway
46 Cytokines and Inflammatory Response
47 Endochondral Ossification
48 MAPK Signaling Pathway
49 TGF beta Signaling Pathway
50 NRF2 pathway
51 Nuclear Receptors Meta-Pathway
52 Vitamin D Receptor Pathway
53 Aryl Hydrocarbon Receptor Pathway
54 Extracellular vesicle-mediated signaling in recipient cells
55 Dopaminergic Neurogenesis
56 Endoderm Differentiation
57 Hematopoietic Stem Cell Differentiation
58 Differentiation Pathway
59 Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
60 Cardiac Hypertrophic Response
61 Syndecan interactions
62 Host Interactions with Influenza Factors
63 Transcriptional Regulation of White Adipocyte Differentiation
64 Signaling by TGF-beta Receptor Complex
65 Extracellular matrix organization
66 Elastic fibre formation
67 Primary Focal Segmental Glomerulosclerosis FSGS
68 Spinal Cord Injury
69 Cardiac Progenitor Differentiation
70 Integrated Pancreatic Cancer Pathway
71 Adipogenesis
72 Corticotropin-releasing hormone
73 Allograft Rejection
74 Cell Cycle
75 TFs Regulate miRNAs related to cardiac hypertrophy
76 MicroRNAs in cardiomyocyte hypertrophy
77 Oxidative Stress
78 Prostaglandin Synthesis and Regulation
79 Arachidonic acid metabolism
80 Aryl Hydrocarbon Receptor
81 Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
82 Eicosanoid Synthesis
83 Selenium Micronutrient Network
84 Toll-like receptor signaling pathway
85 Estrogen signaling pathway
86 NLR Proteins
87 Hair Follicle Development: Induction (Part 1 of 3)
88 MyD88 cascade initiated on plasma membrane
89 Cytosolic sensors of pathogen-associated DNA
90 MyD88 dependent cascade initiated on endosome
91 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
92 MyD88:Mal cascade initiated on plasma membrane
93 Fc epsilon receptor (FCERI) signaling
94 Signaling by the B Cell Receptor (BCR)
95 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
96 Structural Pathway of Interleukin 1 (IL-1)
97 EBV LMP1 signaling
98 Polycystic Kidney Disease Pathway
99 Apoptosis
100 AGE/RAGE pathway
101 TNF alpha Signaling Pathway
102 IL17 signaling pathway
103 TWEAK Signaling Pathway
104 RANKL/RANK Signaling Pathway
105 Signalling by NGF
106 TCR signaling
107 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
108 Interleukin-1 signaling
109 Apoptosis Modulation and Signaling
110 Type II diabetes mellitus
111 Regulation of toll-like receptor signaling pathway
112 Osteopontin Signaling
113 NOD pathway
114 Serotonin Receptor 2 and STAT3 Signaling
115 Notch Signaling Pathway
116 EPO Receptor Signaling
117 Estrogen Receptor Pathway
118 TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
119 Transcriptional regulation of pluripotent stem cells
120 Mammary gland development pathway - Involution (Stage 4 of 4)
121 Growth hormone receptor signaling
122 IL-9 Signaling Pathway
123 IL-7 Signaling Pathway
124 Regulation of Microtubule Cytoskeleton
125 TSH signaling pathway
126 Cell Differentiation - Index
127 Cell Differentiation - meta
128 NGF signalling via TRKA from the plasma membrane
129 Physiological and Pathological Hypertrophy of the Heart
130 Androgen receptor signaling pathway
131 SIDS Susceptibility Pathways
132 Integrated Breast Cancer Pathway
133 Nuclear Receptors
134 Apoptosis Modulation by HSP70
135 Myometrial Relaxation and Contraction Pathways
136 IL1 and megakaryotyces in obesity
137 Apoptosis-related network due to altered Notch3 in ovarian cancer
138 Hair Follicle Development: Organogenesis (Part 2 of 3)
139 Selenium Metabolism and Selenoproteins
140 T-Cell Receptor and Co-stimulatory Signaling
141 Neural Crest Differentiation
142 Interleukin-1 processing
143 Folate Metabolism
144 Vitamin B12 Metabolism
References
Reference 1 Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells. Cancer Med. 2018 Sep;7(9):4610-4618.
Reference 2 Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase. Eur J Pharmacol. 2021 Jan 5;890:173647.
Reference 3 Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells. Cancer Lett. 2012 Mar;316(1):11-22.
Reference 4 Cryptotanshinone Protects Cartilage against Developing Osteoarthritis through the miR-106a-5p/GLIS3 Axis. Mol Ther Nucleic Acids. 2018 Jun 1;11:170-179.
Reference 5 Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells. Arch Toxicol. 2016 Sep;90(9):2275-2286.
Reference 6 Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer's disease. Pharmacol Res. 2018 Mar;129:482-490.
Reference 7 Cryptotanshinone protects against pulmonary fibrosis through inhibiting Smad and STAT3 signaling pathways. Pharmacol Res. 2019 Sep;147:104307.
Reference 8 Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1). Br J Pharmacol. 2015 Dec;172(23):5661-75.
Reference 9 Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation. Cell Death Dis. 2017 May 11;8(5):e2767.
Reference 10 Activation of dynamin-related protein 1 - dependent mitochondria fragmentation and suppression of osteosarcoma by cryptotanshinone. J Exp Clin Cancer Res. 2019 Jan 28;38(1):42.
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