Drug Combination Details
| General Information of the Combination (ID: C33060) | |||||
|---|---|---|---|---|---|
| Name | Fisetin NP Info | + | Cabazitaxel Drug Info | ||
| Structure |
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| Disease |
Prostate cancer
[ICD-11: 2C82]
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Investigative | [1] | ||
| Combinatorial Therapeutic Effect(s) Validated Clinically or Experimentally | ||||||
|---|---|---|---|---|---|---|
| α. Enhancing Drug Efficacy by This Combination | ||||||
| Achieving Therapeutic Synergy | Click to Show/Hide | |||||
| Experiment 1 Reporting the Effect of This Combination | [1] | |||||
| Molecule(s)
Regulation |
Down-regulation | Expression | ABCB1 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | BAX | Molecule Info |
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| Up-regulation | Expression | MCL1 | Molecule Info |
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| Down-regulation | Expression | MKI67 | Molecule Info | |||
| Down-regulation | Expression | MMP-2 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | MMP-9 | Molecule Info |
Pathway MAP
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| Up-regulation | Expression | PARP1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PCNA | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PECAM1 | Molecule Info |
Pathway MAP
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| Down-regulation | Expression | PRAP1 | Molecule Info |
Pathway MAP
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| In-vitro Model | LNCaP C4-2 | CVCL_4782 | Prostate carcinoma | Homo sapiens | ||
| A-549 | CVCL_0023 | Lung adenocarcinoma | Homo sapiens | |||
| PrEC | Prostate cancer | Homo sapiens | ||||
| 22Rv1 | Prostate cancer | Homo sapiens | ||||
| In-vivo Model | A total of 24 athymic nude male mice 6-8 weeks old were injected subcutaneously with 1*106 22Rv1 cells. | |||||
| Experimental
Result(s) |
Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells. | |||||
| References | ||||
|---|---|---|---|---|
| Reference 1 | Fisetin Enhances Chemotherapeutic Effect of Cabazitaxel against Human Prostate Cancer Cells. Mol Cancer Ther. 2016 Dec;15(12):2863-2874. | |||
